ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2023
Multi-site comparison of parametric T1 and T2 mapping: healthy travelling volunteers in the Berlin research network for cardiovascular magnetic resonance (BER-CMR).
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Society for Cardiovascular Magnetic Resonance reference values ("normal values") in cardiovascular magnetic resonance: 2025 update.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Guideline
- Technical challenges in establishing local native T1 reference ranges in cardiac MRI: a critical review.Insights into imaging · 2026Review
- Native myocardial T1 reference values in a tunisian cohort using MOLLI and SMART1Map.Scientific reports · 2026Article
- Impaired pulmonary function associated with subclinical myocardial injury in primary Sjögren's syndrome: a preliminary cardiac magnetic resonance study.Clinical rheumatology · 2026Article
- Deep learning-based segmentation of T1 and T2 cardiac MRI maps for automated disease detection.European radiology · 2026Article
- Scan-rescan reproducibility and interobserver reliability of T1 and T2 measurements of extraocular muscles using a multi-dynamic multi-echo MRI sequence.BMC medical imaging · 2026Article
- Reproducibility assessment of biventricular strain derived from Long-Axis feature tracking in travelling Volunteers - A study in the Berlin research network for cardiovascular magnetic resonance (BER-CMR).The international journal of cardiovascular imaging · 2025Article
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- Misclassification of females and males in cardiovascular magnetic resonance parametric mapping: the importance of sex-specific normal ranges for diagnosis of health vs. disease.European heart journal. Cardiovascular Imaging · 2024Article
- Inter-site comparability of 4D flow cardiovascular magnetic resonance measurements in healthy traveling volunteers-a multi-site and multi-magnetic field strength study.Frontiers in cardiovascular medicine · 2024Article
- Trajectories of functional and structural myocardial parameters in post-COVID-19 syndrome-insights from mid-term follow-up by cardiovascular magnetic resonance.Frontiers in cardiovascular medicine · 2024Article
- Confounders, diagnostic accuracy, and reproducibility in cardiovascular magnetic resonance-feature tracking-derived left atrial strain: A Berlin Research Network for cardiovascular magnetic resonance multi-software, multi-site comparison.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParametric mapping sequences in cardiovascular magnetic resonance (CMR) allow for non-invasive myocardial tissue characterization. However quantitative myocardial mapping is still limited by the need for local reference values. Confounders, such as field strength, vendors and sequences, make intersite comparisons challenging. This exploratory study aims to assess whether multi-site studies that control confounding factors provide first insights whether parametric mapping values are within pre-defined tolerance ranges across scanners and sites.
methodsA cohort of 20 healthy travelling volunteers was prospectively scanned at three sites with a 3 T scanner from the same vendor using the same scanning protocol and acquisition scheme. A Modified Look-Locker inversion recovery sequence (MOLLI) for T1 and a fast low-angle shot sequence (FLASH) for T2 were used. At one site a scan-rescan was performed to assess the intra-scanner reproducibility. All acquired T1- and T2-mappings were analyzed in a core laboratory using the same post-processing approach and software.
resultsAfter exclusion of one volunteer due to an accidentally diagnosed cardiac disease, T1- and T2-maps of 19 volunteers showed no significant differences between the 3 T sites (mean ± SD [95% confidence interval] for global T1 in ms: site I: 1207 ± 32 [1192-1222]; site II: 1207 ± 40 [1184-1225]; site III: 1219 ± 26 [1207-1232]; p = 0.067; for global T2 in ms: site I: 40 ± 2 [39-41]; site II: 40 ± 1 [39-41]; site III 39 ± 2 [39-41]; p = 0.543).
conclusionParametric mapping results displayed initial hints at a sufficient similarity between sites when confounders, such as field strength, vendor diversity, acquisition schemes and post-processing analysis are harmonized. This finding needs to be confirmed in a powered clinical trial. Trial registration ISRCTN14627679 (retrospectively registered).
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