ArticleTranslational psychiatry2023
Age-, sex-, and pathology-related variability in brain structure and cognition.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Mapping Neuroanatomical Heterogeneity of Brain Aging Within a Clinically Defined Aging Reference Cohort.Bioengineering (Basel, Switzerland) · 2026Article
- Physical function impacts hearing without mediation from systolic blood pressure.Scientific reports · 2026Article
- Independent and interactive contributions of white matter hyperintensities and Alzheimer's disease imaging and plasma biomarkers to cognitive decline in older adults without dementia.Alzheimer's research & therapy · 2026Article
- Low-density lipoprotein cholesterol modulates amyloid-related entorhinal vulnerability and episodic memory performance in older adults.Frontiers in aging neuroscience · 2026Article
- Protective Effects of Socioeconomic Status and Lifestyle on Amyloid- and White Matter Hyperintensity-Related Longitudinal Brain Atrophy and Cognitive Decline.Annals of neurology · 2025Article
- Predicting cognitive decline with amyloid-PET, plasma p-tau217, Aβ42/40, and p-tau217/Aβ42 in a community-based cohort - relevance for clinical trial enrollment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Altered T-cell reactivity in the early stages of Alzheimer's disease.Brain : a journal of neurology · 2025Article
- Deep Brain Stimulation in Parkinson's Disease Patients Over 75 Years of Age: A Single-Institution Retrospective Analysis.CNS neuroscience & therapeutics · 2025Article
- Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain.BMC nursing · 2025Article
- A meta-analysis of the effects of DBS on cognitive function in patients with advanced PD.Open medicine (Warsaw, Poland) · 2025Review
- Brain-Cognition Fingerprinting via Graph-GCCA with Contrastive Learning.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025Article
- CSF levels of brain-derived proteins correlate with brain ventricular volume in cognitively healthy 70-year-olds.Clinical proteomics · 2024Article
- Hypertension and cerebral blood flow in the development of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition.Alzheimer's research & therapy · 2024Article
- Development and validation of a cognitive dysfunction risk prediction model for the abdominal obesity population.Frontiers in endocrinology · 2024Article
- Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization.Brain communications · 2024Article
- Explaining variability in early stages of [18F]-flortaucipir tau-PET binding: Focus on sex differences.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Hippocampal mediation in the lipid-Alzheimer's disease pathway: A high-dimensional mediation analysis stratified byAlzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work aimed to investigate potential pathways linking age and imaging measures to early age- and pathology-related changes in cognition. We used [18F]-Flutemetamol (amyloid) and [18F]-Flortaucipir (tau) positron emission tomography (PET), structural MRI, and neuropsychological assessment from 232 elderly individuals aged 50-89 years (46.1% women, 23% APOE-ε4 carrier, 23.3% MCI). Tau-PET was available for a subsample of 93 individuals. Structural equation models were used to evaluate cross-sectional pathways between age, amyloid and tau burden, grey matter thickness and volumes, white matter hyperintensity volume, lateral ventricle volume, and cognition. Our results show that age is associated with worse outcomes in most of the measures examined and had similar negative effects on episodic memory and executive functions. While increased lateral ventricle volume was consistently associated with executive function dysfunction, participants with mild cognitive impairment drove associations between structural measures and episodic memory. Both age and amyloid-PET could be associated with medial temporal lobe tau, depending on whether we used a continuous or a dichotomous amyloid variable. Tau burden in entorhinal cortex was related to worse episodic memory in individuals with increased amyloid burden (Centiloid >12) independently of medial temporal lobe atrophy. Testing models for sex differences revealed that amyloid burden was more strongly associated with regional atrophy in women compared with men. These associations were likely mediated by higher tau burden in women. These results indicate that influences of pathological pathways on cognition and sex-specific vulnerabilities are dissociable already in early stages of neuropathology and cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.