ArticleCancer causes & control : CCC2024
The impact of in-house pathology services on downstaging cervical cancer in Tanzania over an 18-year period.
Article in Cancer causes & control : CCC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Nutritional status of patients diagnosed with cervical cancer in Tanzania.BMC nutrition · 2026Article
- Changes in cervical cancer stage at diagnosis in Zambia over 15 years.Cancer causes & control : CCC · 2026Article
- Nutritional Status of Patients Diagnosed with Cervical Cancer in Tanzania.Research square · 2025Article
- The Changing Landscape of Cervical Cancer in Africa: Opportunities for Patient, Public, and Professional Education.Journal of cancer education : the official journal of the American Association for Cancer Education · 2024Article
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8 authors.
Funding
Abstract
purposeReducing time between cancer screening, diagnosis, and initiation of treatment is best achieved when services are available in the same hospital. Yet, comprehensive cancer centers are typically unavailable in low- and middle-income countries (LMICs), where resources are limited and services scattered. This study explored the impact of establishing an in-house pathology laboratory at the largest public cancer hospital in Tanzania on the downstaging of cervical cancer.
methodsWe examined clinical datasets of 8,322 cervical cancer patients treated at the Ocean Road Cancer Institute (ORCI). The first period included patients treated from 2002 to 2016, before establishment of the pathology laboratory at ORCI; the second period (post-pathology establishment) included data from 2017 to 2020. Logistic regression analysis evaluated the impact of the pathology laboratory on stage of cervical cancer diagnosis.
resultsPatients treated during the post-pathology period were more likely to be clinically diagnosed at earlier disease stages compared to patients in the pre-pathology period (pre-pathology population diagnosed at early disease stage: 44.08%; post-pathology population diagnosed at early disease stage: 59.38%, p < 0.001). After adjustment for age, region of residence, and place of biopsy, regression results showed patients diagnosed during the post-pathology period had higher odds of early stage cervical cancer diagnosis than patients in the pre-pathology period (OR 1.35, 95% CI (1.16, 1.57), p < 0.001).
conclusionsIntegrated and comprehensive cancer centers can overcome challenges in delivering expedited cervical cancer diagnosis and treatment. In-house pathology laboratories play an important role in facilitating timely diagnosis and rapid treatment of cervical and possibly other cancers in LMICs.
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