Hitting the brakes on transcription to extend lifespan.

Kristopher Burkewitz

Open access · greenAbstract read

In one paragraph

Article in Trends in genetics : TIG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.Nature communications · 2025
Article
ConsideringCells · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kristopher BurkewitzDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA. Electronic address: kristopher.burkewitz@vanderbilt.edu.

Vanderbilt University · US

Funding

Targeting ER-mitochondrial calcium signaling to promote healthier agingR01AG073354 · NIA · VANDERBILT UNIVERSITY · PI Kristopher Burkewitz · 2022 to 2026

$1.6M

Unconventional regulation of mTORC1 signaling by inositol phosphate: implications for nutrient-induced premature agingR21AG071975 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLIND, RAYMOND DANIEL, BURKEWITZ, KRISTOPHER · 2022 to 2023

$483k

NIA NIH HHS R01 AG073354NIA NIH HHS R21 AG071975

6 · The paper itself

Abstract

In aged animals from worms to humans, transcriptional elongation rates are faster, leading to changes in transcript quality and alternative splicing. Recent work by Debès et al. shows how interventions that slow elongation rates, such as mutating RNA polymerase II (Pol II) or increasing nucleosome density to impose transcriptional 'traffic', delay senescence and promote longevity.

Indexed as

LongevityTranscription, GeneticAgedAlternative SplicingAnimalsHumansNucleosomesRNA Polymerase IINucleosomesRNA Polymerase IIagingalternative splicingCaenorhabditis eleganschromatinDrosophila melanogasterhistoneshumanlongevitymouseratRNARNA polymerase IIsenescencetranscriptiontranscriptional elongation

Identifiers

PMID37574379

DOI10.1016/j.tig.2023.07.007

PMCPMC10841265

OpenAlexW4385782562

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.