ArticleCellular and molecular gastroenterology and hepatology2023
Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma.
Article in Cellular and molecular gastroenterology and hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Eosinophils in solid cancers: sentinels, predictors, and therapeutic allies.Journal of experimental & clinical cancer research : CR · 2026Review
- Diagnostic Stratification of Prostate Cancer Through Blood-Based Biochemical and Inflammatory Markers.Diagnostics (Basel, Switzerland) · 2025Article
- Harnessing myeloid cells in cancer.Molecular cancer · 2025Review
- The role of IL-33/ST2 axis in esophageal inflammatory diseases and cancers: implications for the immunopathogenesis and immunotherapeutic target?Therapeutic advances in gastroenterology · 2025Review
- No Association Between Eosinophilic Oesophagitis and Oesophageal Cancer in US Adults: A Case-Control Study.Alimentary pharmacology & therapeutics · 2025Article
- Risk of Cancer Diagnosis in Patients With Eosinophilic Esophagitis Using a Nationwide Swedish Population Cohort.United European gastroenterology journal · 2024Article
- Advancing toward a unified eosinophil signature from transcriptional profiling.Journal of leukocyte biology · 2024Review
- Squamous Cell Carcinoma with Prominent Eosinophils.Head and neck pathology · 2024Review
- Assessment of Tumor-Associated Tissue Eosinophilia (TATE) and Tumor-Associated Macrophages (TAMs) in Canine Transitional Cell Carcinoma of the Urinary Bladder.Animals : an open access journal from MDPI · 2024Article
- The Underappreciated Role of Eosinophils in Esophageal Cancer.Cellular and molecular gastroenterology and hepatology · 2023Article
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Authors and funding
22 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsEosinophils are present in several solid tumors and have context-dependent function. Our aim is to define the contribution of eosinophils in esophageal squamous cell carcinoma (ESCC), as their role in ESCC is unknown.
methodsEosinophils were enumerated in tissues from 2 ESCC cohorts. Mice were treated with 4-NQO for 8 weeks to induce precancer or 16 weeks to induce carcinoma. The eosinophil number was modified by a monoclonal antibody to interleukin-5 (IL5mAb), recombinant IL-5 (rIL-5), or genetically with eosinophil-deficient (ΔdblGATA) mice or mice deficient in eosinophil chemoattractant eotaxin-1 (Ccl11
resultsActivated eosinophils are present in higher numbers in early-stage vs late-stage ESCC. Mice treated with 4-NQO exhibit more esophageal eosinophils in precancer vs cancer. Correspondingly, epithelial cell Ccl11 expression is higher in mice with precancer. Eosinophil depletion using 3 mouse models (Ccl11
conclusionEosinophils likely protect against ESCC through reactive oxygen species release during degranulation and suppression of IL-17.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.