Evidence map›Paper›PMID 37573625›Full record

ReviewCurrent opinion in biotechnology2023

Sustainable metabolic engineering requires a perfect trifecta.

Glenn Nurwono, Samantha O'Keeffe, Nian Liu, Junyoung O Park

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Glenn NurwonoDepartment of Chemistry and Biochemistry, USA.
Samantha O'KeeffeDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
Nian LiuDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA. Electronic address: steven.liu.91515@gmail.com.
Junyoung O ParkDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA. Electronic address: jop@ucla.edu.

Funding

Molecular basis linking metabolic heterogeneity, compatibility, and adaptabilityR35GM143127 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Junyoung O. Park · 2021 to 2026
$2.5M
NIGMS NIH HHS R35 GM143127
6 · The paper itself

Abstract

The versatility of cellular metabolism in converting various substrates to products inspires sustainable alternatives to conventional chemical processes. Metabolism can be engineered to maximize the yield, rate, and titer of product generation. However, the numerous combinations of substrate, product, and organism make metabolic engineering projects difficult to navigate. A perfect trifecta of substrate, product, and organism is prerequisite for an environmentally and economically sustainable metabolic engineering endeavor. As a step toward this endeavor, we propose a reverse engineering strategy that starts with product selection, followed by substrate and organism pairing. While a large bioproduct space has been explored, the top-ten compounds have been synthesized mainly using glucose and model organisms. Unconventional feedstocks (e.g. hemicellulosic sugars and CO

Indexed as

Metabolic EngineeringSugarsGlucoseGlucoseSugars

Identifiers

PMID37573625
PMCPMC10960266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.