ArticleJPEN. Journal of parenteral and enteral nutrition2023
Predictors of 1-year enteral autonomy in children with intestinal failure: A descriptive retrospective cohort study.
Article in JPEN. Journal of parenteral and enteral nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Serial Transverse Enteroplasty and the Reestablishment of Enteral Autonomy Among the Adult Population: New Insights With Advanced Clinical Practice and Novel Outcome Predictive Model.Annals of surgery · 2026Article
- Predictors of response and enteral autonomy in children with short bowel syndrome treated with teduglutide: a real-life multicentre cohort study.EClinicalMedicine · 2025Article
- Updates in Intestinal Failure Management.Journal of clinical medicine · 2025Review
- Social and Financial Costs of Neonatal Intestinal Failure.JAMA network open · 2025Article
- The Development of the International Intestinal Failure Registry and an Overview of its Results.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2024Review
- Review of cost-effectiveness analysis to study pediatric intestinal failure and transplant.Intestinal Failure (New York, N.Y.)Article
- Caregiver perspectives on barriers and facilitators to pediatric intestinal failure quality of life.Intestinal Failure (New York, N.Y.)Article
- Development of a registry to evaluate immobilized lipase cartridge use in pediatric patients with short bowel syndrome/intestinal failure.Intestinal Failure (New York, N.Y.)Article
- Evolution of gastrostomy tube management in a pediatric intestinal rehabilitation program.Intestinal Failure (New York, N.Y.)Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionThe International Intestinal Failure Registry (IIFR) is an international consortium to study intestinal failure (IF) outcomes in a large contemporary pediatric cohort. We aimed to identify predictors of early (1-year) enteral autonomy.
methodsWe included IIFR pilot phase patients. IF was defined by a parenteral nutrition need for at least 60 days due to a primary gastrointestinal etiology. The primary outcome was time to enteral autonomy achievement. We built a mixed-effects Weibull accelerated failure time model with random effects by center to analyze variables associated with enteral autonomy achievement with a primary outcome of time ratio (TR).
resultsWe included 189 patients (82% with short bowel syndrome) representing 11 international centers. Cumulative incidence of early enteral autonomy was 51.6%, and death was 6.5%. In multivariable analysis, ostomy presence (TR, 2.63; 95% CI, 1.41-4.90) was associated with increased time to enteral autonomy achievement, and Asian/Indian (TR, 0.28; 95% CI, 0.10-0.81) and Pacific Islander race (TR, 0.34; 95% CI, 0.13-0.90) were associated with decreased time to enteral autonomy achievement. In a second model in the subset with measured percentage of bowel length remaining, ostomy presence (TR, 4.21; 95% CI, 1.90-9.33) was associated with increased time to enteral autonomy achievement, whereas greater percentage of bowel remaining (TR, 0.96; 95% CI, 0.94-0.98) was associated with decreased time to enteral autonomy achievement.
conclusionsMinimizing bowel resection at initial surgery and establishing bowel continuity by ostomy reversal can effectively decrease the time to early enteral autonomy achievement in children with IF.
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