ArticleNature communications2023
Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Comparative efficacy of different modalities of transcranial magnetic stimulation for treating Parkinson's disease with depression: a systematic review and network meta-analysis.Frontiers in neurology · 2025Pooled it
- Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top-Down Middle Cingulate Amygdala Regulation and Brain-Wide Fear Representations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Prediction of generalized anxiety disorder treatment outcomes with neurobehavioral responses to approach-avoidance conflict: a randomized clinical trial.Translational psychiatry · 2025Trial
- Article
- Childhood trauma and impulsivity in children with first-episode depression: mediation by left frontopolar thickness.BMC psychiatry · 2026Article
- Identifying neuroimaging biomarkers for anxiety in emerging adults using machine learning and functional near-infrared spectroscopy during resting-state.Frontiers in psychiatry · 2026Article
- Mindfulness-based intervention for patients with generalized anxiety disorder: a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Closed-loop acoustic stimulation modified by cathodal tDCS is beneficial for retention.bioRxiv : the preprint server for biology · 2025Article
- Transient frontopolar cortex stimulation induces prolonged disruption to counterfactual processing.PLoS biology · 2025Article
- Article
- Influence of the HPA Axis on Anxiety-Related Processes: An RDoC Overview Considering Their Neural Correlates.Current psychiatry reports · 2025Review
- An Exploratory Study on the Regulatory Effect of Autonomous Sensory Meridian Response on Anxiety: Evidence From Functional Near-Infrared Brain Imaging Technology.The European journal of neuroscience · 2025Article
- Prelimbic Cortex Activity Predicts Anxiety-Like Behavior in the Elevated Plus Maze.The European journal of neuroscience · 2025Article
- Reduced neural activation during positive social approach is associated with better response to approach avoidance training for social anxiety disorder.Journal of mood and anxiety disorders · 2025Article
- Lateral frontopolar theta-band activity supports flexible switching between emotion regulation strategies.Scientific reports · 2025Article
- Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial.Journal of mood and anxiety disorders · 2025Article
- Generalized anxiety disorder patients' cognitive control in affective contexts.Frontiers in psychiatry · 2025Article
- Article
- E-Skin and Its Advanced Applications in Ubiquitous Health Monitoring.Biomedicines · 2024Review
- Metacognition as a window into subjective affective experience.Psychiatry and clinical neurosciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive avoidance, a trait that prevents learning through exposure. Although the origin of this failure is unclear, one candidate system involves control of emotional actions, coordinated through lateral frontopolar cortex (FPl) via amygdala and sensorimotor connections. Using structural, functional, and neurochemical evidence, we show how FPl-based emotional action control fails in highly-anxious individuals. Their FPl is overexcitable, as indexed by GABA/glutamate ratio at rest, and receives stronger amygdalofugal projections than non-anxious male participants. Yet, high-anxious individuals fail to recruit FPl during emotional action control, relying instead on dorsolateral and medial prefrontal areas. This functional anatomical shift is proportional to FPl excitability and amygdalofugal projections strength. The findings characterize circuit-level vulnerabilities in anxious individuals, showing that even mild emotional challenges can saturate FPl neural range, leading to a neural bottleneck in the control of emotional action tendencies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.