ArticleNature communications2023
Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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0cells of the map it votes in
28citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
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Who cites it
28 citing papers in PubMed, 31 citations in OpenAlex.
- Lipid flip-flop in biological membranes: through the lens of TMEM16F.Physiological reviews · 2026Review
- Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling.bioRxiv : the preprint server for biology · 2026Article
- Recent advances in TMEM16F: structural plasticity, functional versatility, and implications for human diseases.Cell communication and signaling : CCS · 2026Review
- Calcium dependent activation of the TMEM16F scramblase and ion channel.Nature structural & molecular biology · 2026Article
- Targeting virus-interacting host ion channels as a novel antiviral strategy.Acta pharmacologica Sinica · 2026Review
- Mechanism of Phosphatidylserine Lipid Scrambling by Human SERINC3, an HIV-1 Restriction Factor.bioRxiv : the preprint server for biology · 2025Article
- T cell cholesterol transport links intestinal immune responses to dietary lipid absorption.Science (New York, N.Y.) · 2025Article
- Exploring Niclosamide as a Multi-target Drug Against SARS-CoV-2: Molecular Dynamics Simulation Studies on Host and Viral Proteins.Molecular biotechnology · 2025Article
- Article
- Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection.Science advances · 2025Article
- Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove.eLife · 2025Article
- Groove architecture controls lipid scrambling in simulations of protein and model systems.bioRxiv : the preprint server for biology · 2025Article
- ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATION.Shock (Augusta, Ga.) · 2025Article
- Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove.bioRxiv : the preprint server for biology · 2025Article
- Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families.Nature structural & molecular biology · 2025Review
- TMEM16F regulates pathologic α-synuclein secretion and spread in cellular and mouse models of Parkinson's disease.Aging cell · 2025Article
- HEK293 Cell-Based Assay to Measure the Lipid Scrambling Activity of TMEM16 Family Members.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Mechanism of action and therapeutic value of anoctamin-1 in gastrointestinal cancers.Frontiers in immunology · 2025Review
- Distinct modulation of calcium-activated chloride channel TMEM16A by drug-binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
- Update of
Authors and funding
15 authors at 2 institutions in 1 country.
Shengjie Feng *Department of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Cristina Puchades *Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3240-4176
Juyeon KoDepartment of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3221-9483
Hao WuDepartment of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Yifei ChenHoward Hughes Medical Institute; UCSF, San Francisco, CA, USA.
Eric E FigueroaDepartment of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8562-6552
Shuo GuBioDuro-Sundia Inc., Irvine, CA, USA.
Tina W HanDepartment of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Brandon HoDepartment of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Tong ChengHoward Hughes Medical Institute; UCSF, San Francisco, CA, USA.
Junrui LiDepartment of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Brian ShoichetDepartment of Pharmaceutical Chemistry, University of California San Francisco (UCSF) School of Pharmacy, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6098-7367
Yuh Nung JanDepartment of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1367-6299
Yifan ChengDepartment of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA. Yifan.Cheng@ucsf.edu.ORCID http://orcid.org/0000-0001-9535-0369
Lily Yeh JanDepartment of Physiology, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA. Lily.Jan@ucsf.edu.ORCID http://orcid.org/0000-0003-3938-8498
University of California, San Francisco · USHoward Hughes Medical Institute · US
Funding
UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MDIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3MMolecular, Genetic & Physiological Studies of Calcium-activated Chloride ChannelsR01NS069229 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAN, LILY Y · 2011 to 2020
$3.5MThe TMEM16 Family of Ion Channels and Lipid ScramblasesR35NS122110 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LILY JAN · 2021 to 2026
$3.2MAdvancing cryo-EM technology to address difficult biological questionsR35GM140847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yifan Cheng · 2021 to 2026
$2.1MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MGlacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8MLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kNIDDK NIH HHS T32 DK007418NIGMS NIH HHS K12 GM081266NIGMS NIH HHS R35 GM140847NIH HHS S10 OD020054NIH HHS S10 OD021741NIH HHS S10 OD026881NINDS NIH HHS R01 NS069229NINDS NIH HHS R35 NS122110
Abstract
The dual functions of TMEM16F as Ca
Indexed as
AnoctaminsCOVID-19CalciumCalcium ChannelsHumansLipidsNiclosamidePhospholipid Transfer ProteinsSARS-CoV-2AnoctaminsCalciumCalcium ChannelsLipidsNiclosamidePhospholipid Transfer Proteins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.