ArticleJournal of cancer research and clinical oncology2023
Psychiatric disorder and its association with gastrointestinal cancer: a retrospective cohort study with 45,842 patients in Germany.
Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Antidepressant use in German adolescents with a first recorded diagnosis of depression: a retrospective cohort study.European child & adolescent psychiatry · 2026Article
- Exploring the Influence of Sex and Gender on Cancer: A Comprehensive Analysis.Cancer medicine · 2025Article
- Long-Term Risk of Pancreatic Cancer After Acute Acetylcholinesterase Inhibitor Insecticide Exposure: A Nationwide Cohort Study.Current oncology (Toronto, Ont.) · 2025Article
- Cancer in Severe Mental Illness Patients: A Retrospective Study.Psycho-oncology · 2025Article
- Prevalence of Antidepressant Prescription in Adolescents Newly Diagnosed with Depression in Germany.Children (Basel, Switzerland) · 2024Article
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
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Abstract
purposePsychiatric disorders and cancer are both common, and comorbidity has detrimental impacts on cancer outcomes. Previous studies focus on affective disorders which arise after cancer diagnosis, not on the impact of psychiatric disorders on cancer risk. We investigate the association between psychiatric disorders and subsequent gastrointestinal cancer in a large cohort in Germany.
methodsThis case-control study used secondary data (electronic medical records) from the national IQVIA Disease Analyzer database. We evaluated the association between previous psychiatric diagnosis in 44,582 matched patients with and without gastrointestinal (GI) cancer. Regression analyses were stratified by psychiatric diagnosis and adjusted by chronic comorbidities and previous psychiatric treatments.
resultsNo association between any previous psychiatric disease and GI cancers was found (OR = 0.98 (0.95-1.02 95%CL, p = 0.39). Previous psychosomatic disorder and GI cancer showed a significant negative association (OR: 0.86, 0.81-0.90 95%CL, p < 0.0001). No association was found between previous diagnosis with depression or PTSD and GI cancer. These results remained consistent when including previous psychiatric treatments in the regression analyses.
conclusionPsychiatric disease was not associated with GI cancer risk. Further investigation into the pathways linking psychiatric disease and cancer needs to be conducted, taking into consideration psychiatric treatments administered, to enhance our understanding of the relationship between these two common and devastating diseases.
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