Observational studyThe American journal of medicine2023
Clinical Significance of Right Heart Thrombus With and Without an Associated Pulmonary Embolism.
Observational study in The American journal of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Cinematic rendering-enhanced computed tomography of right intracardiac thrombi: A case report.Radiology case reports · 2026Article
- Thrombus in Transit Following Hemodynamic Stabilization in Acute Pulmonary Embolism: A Therapeutic Dilemma.Cureus · 2026Article
- Prognostic Significance of Echocardiography-Visualized Thrombus in Right Heart in Early Stages of Acute PE: 100 Patients from Regional Pulmonary Embolism Registry.Life (Basel, Switzerland) · 2026Article
- Right Ventricular Thrombus Presenting With Right Ventricular Failure in Septic Shock: A Case Report.Cureus · 2026Article
- Abrupt formation and spontaneous resolution of a mobile right atrial thrombus following intraoperative cardiopulmonary resuscitation during da Vinci robotic-assisted surgery: a case report.International journal of emergency medicine · 2025Article
- Article
- Article
- Right and Left Ventricle Thrombus in a 68-Year-Old Patient With Sepsis and Cardiomyopathy.Cureus · 2025Article
- A Retrospective Analysis of AngioVac Outcomes at a Tertiary Care Center.Journal of the Society for Cardiovascular Angiography & Interventions · 2024Article
- Clinical Outcomes and Predictors of Advanced Therapy for the Management of Right Heart Thrombus.Circulation. Cardiovascular interventions · 2024Observational
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRight heart thrombus is a rare but serious form of venous thromboembolic disease that may be associated with pulmonary embolism. The prognosis of patients with right heart thrombus presenting without a concomitant pulmonary embolism remains ill-defined.
methodsWe conducted a multi-center observational cohort study to compare patients presenting with right heart thrombus with and without a concurrent pulmonary embolism. The primary endpoint was 90-day all-cause mortality. Multivariable regression was utilized to assess primary and secondary outcomes.
resultsOf 231 patients with right heart thrombus, 104 (45.0%) had a pulmonary embolism at admission. The median age of the cohort was 59.4 years (interquartile range 44.9-71.3). Pulmonary embolism in the setting of a right heart thrombus was associated with an increased adjusted hazard of 90-day mortality (hazard ratio 3.68; 95% confidence interval [CI], 1.51-8.97). Additionally, these patients had a higher adjusted risk of in-hospital mortality (odds ratio [OR] 2.55; 95% CI, 1.15-5.94) and admission to the intensive care unit (OR 2.45; 95% CI, 1.23-4.94). Thrombus mobility (OR 2.99; 95% CI, 1.35-6.78) and larger thrombus sizes (OR 1.04; 95% CI, 1.00-1.07) were associated with development of concurrent pulmonary embolism.
conclusionsPatients with right heart thrombus and pulmonary embolism had a more severe clinical presentation, required more advanced therapies, and had reduced survival compared with those without a concomitant pulmonary embolism. Important variables associated with development of concomitant pulmonary embolism include thrombus mobility and size. Right heart thrombus in the setting of acute pulmonary embolism represents a unique clinical entity that is associated with worse prognosis compared with right heart thrombus only.
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