ArticleImmunity2023
Loss of CD4
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Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
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Who cites it
36 citing papers in PubMed, 47 citations in OpenAlex.
- Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026Review
- Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis.mBio · 2026Article
- Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review).International journal of molecular medicine · 2026Review
- A conserved grain-associated immunosuppressive niche in Sudanese patients with mycetoma.PLoS neglected tropical diseases · 2026Observational
- GFPT2 promotes macrophage dysfunction in atherosclerosis via ACADL glycosylation-dependent suppression of ACADL and Arg1.Cellular and molecular life sciences : CMLS · 2026Article
- PDE4B deficiency aids macrophage differentiation and contributes to Cryptococcus neoformans brain infection.PLoS pathogens · 2026Article
- Single-cell transcriptome sequencing reveals immunological mechanisms by which recombinant Echinococcus granulosus P29 protein alleviates airway inflammation in mice with allergic asthma.Parasites & vectors · 2026Article
- The role of T cells in influenza infection and vaccination.Virologica Sinica · 2026Review
- Geniposide Alleviates Inflammatory Bowel Disease by Regulating Intestinal Flora and Arginine Metabolism and Inhibiting the NF-κB Pathway Through Targeting Anxa5.Mediators of inflammation · 2026Article
- ARG1-polyamine axis: cell-type-specific functions in disease pathogenesis and therapeutic targeting.Frontiers in immunology · 2026Review
- Lysosomal acidity and cathepsin L activate eosinophils via ARG1-mediated arginine metabolism in allergic airway inflammation.Nature communications · 2025Article
- Abnormal β-Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pantothenate kinase 4 controls lipid synthesis for T-cell proliferation by modulating coenzyme A and glutaminolysis.Signal transduction and targeted therapy · 2025Article
- Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice.Neurotoxicology · 2025Article
- Inside job: Roles of intracellular C3.The Journal of allergy and clinical immunology · 2025Review
- Metabolic Reprogramming in Respiratory Viral Infections: A Focus on SARS-CoV-2, Influenza, and Respiratory Syncytial Virus.Biomolecules · 2025Review
- Thioredoxin regulates T cell proliferation and aggravates the severity of influenza a virus infection.Scientific reports · 2025Article
- The secret life of complement: challenges and opportunities in exploring functions of the complosome in disease.The Journal of clinical investigation · 2025Review
- A CD4Immunity · 2025Article
- Macrophage hitchhiking nanomedicine for enhanced β-elemene delivery and tumor therapy.Science advances · 2025Article
Corrections and comments
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Authors and funding
24 authors at 11 institutions in 5 countries.
Erin E WestComplement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA. Electronic address: erin.west@nih.gov.
Nicolas S MerleComplement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Marcin M KamińskiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Gustavo PalaciosDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Dhaneshwar KumarImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
Luopin WangDepartments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA.
Jack A BibbyComplement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Kirsten OverdahlImmunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, USA.
Alan K JarmuschImmunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC, USA.
Simon FreeleySchool of Immunology and Microbial Sciences, King's College London, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK.
Duck-Yeon LeeBiochemistry Core, NHLBI, NIH, Bethesda, MD, USA.
J Will ThompsonProteomics and Metabolomics Shared Resource, Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.
Zu-Xi YuPathology Core, NHLBI, NIH, Bethesda, MD, USA.
Naomi TaylorPediatric Oncology Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA; Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier, CNRS, Montpellier, France.
Marc SitbonPediatric Oncology Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA; Institut de Génétique Moléculaire de Montpellier (IGMM), Université de Montpellier, CNRS, Montpellier, France.
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Andrea BohrerInflammation and Innate Immunity Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
Katrin D Mayer-BarberInflammation and Innate Immunity Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
Behdad AfzaliImmunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
Majid KazemianDepartments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN, USA.
Sabine Scholl-BuergiClinic for Pediatrics I, Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, Austria.
Daniela KarallClinic for Pediatrics I, Inherited Metabolic Disorders, Medical University of Innsbruck, Innsbruck, Austria.
Martina HuemerDivision of Metabolism and Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Pediatric Endocrinology and Diabetology, University Children's Hospital Basel, Basel, Switzerland; Department of Pediatrics, Landeskrankenhaus (LKH) Bregenz, Bregenz, Austria.
Claudia KemperComplement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA. Electronic address: claudia.kemper@nih.gov.
National Institutes of Health · USSt. Jude Children's Research Hospital · USCentre National de la Recherche Scientifique · FRInnsbruck Medical University · ATNational Institute of Allergy and Infectious Diseases · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Environmental Health Sciences · USPurdue University West Lafayette · USDuke University · USGuy's Hospital · GBUniversity of Zurich · CH
Funding
Unravelling immunoregulatory circuits of tissue inflammationZIADK075149 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI AFZALI, BEHDAD · 2019 to 2025
$19.3MThe role of the intracellular complement system - the complosome - in Th1 biologyZIAHL006223 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KEMPER, CLAUDIA · 2017 to 2025
$16.9MPathology CoreZICHL005904 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI YU, ZU XI · 2010 to 2023
$11.6MMass Spectrometry-based Untargeted MetabolomicsZICES103363 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JARMUSCH, ALAN · 2021 to 2025
$6.5MJoint submission for administrative supplement proposal: HIPAA aligned storage and computing solutionR35GM138283 · NIGMS · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2020 to 2024
$2.0MA New Therapy for Bowel Ischemia-Reperfusion InjuryR44DK075149 · NIDDK · THERASOURCE, LLC · PI JACOB, ASHA · 2010 to 2012
$1.2MExpression, regulation, and role of enhancer RNAs in T helper cellsK22HL125593 · NHLBI · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2017 to 2019
$747kNew Therapy for Bowel Ischemia-Reperfusion InjuryR43DK075149 · NIDDK · THERASOURCE, LLC · PI WU, RONGQIAN · 2006 to 2007
$288kIntramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA DK075149Intramural NIH HHS ZIA HL006223NHLBI NIH HHS K22 HL125593NIDDK NIH HHS R43 DK075149NIDDK NIH HHS R44 DK075149NIGMS NIH HHS R35 GM138283
Abstract
Arginase 1 (Arg1), the enzyme catalyzing the conversion of arginine to ornithine, is a hallmark of IL-10-producing immunoregulatory M2 macrophages. However, its expression in T cells is disputed. Here, we demonstrate that induction of Arg1 expression is a key feature of lung CD4
Indexed as
ArginaseInfluenza, HumanAnimalsCD4-Positive T-LymphocytesGlutamineHumansKineticsLungMammalsMiceArg1 protein, mouseArginaseGlutaminearginase 1arginase 1 deficiencyautoimmunitycell metabolismcomplementglutamineIFN-γIL-10influenza infectionTh1 immunity
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.