Evidence map›Paper›PMID 37572455›Full record

ArticleRedox biology2023

Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma.

Fu-Ju Lei, Jung-Ying Chiang, Huan-Jui Chang, Der-Cherng Chen, Hwai-Lee Wang, Hsi-An Yang, Kai-Yu Wei, Yen-Chih Huang, Chi-Chung Wang, Sung-Tai Wei and 1 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fu-Ju LeiGraduate Institute of Clinical Medical Sciences, China Medical University, Taichung, Taiwan.
Jung-Ying ChiangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Neurosurgery, China Medical University Hsinchu Hospital, Hsinchu, Taiwan.
Huan-Jui ChangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Der-Cherng ChenDepartment of Neurosurgery, China Medical University and Hospital, Taichung, Taiwan.
Hwai-Lee WangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Hsi-An YangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Kai-Yu WeiGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Mingdao High School, Taichung, Taiwan.
Yen-Chih HuangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Medical Imaging, China Medical University and Hospital, Taichung, Taiwan.
Chi-Chung WangGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei, Taiwan.
Sung-Tai WeiDivision of Neurosurgery, Department of Surgery, An Nan Hospital, China Medical University, Tainan, Taiwan.
Chia-Hung HsiehGraduate Institute of Clinical Medical Sciences, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address: chhsiehcmu@mail.cmu.edu.tw.
China Medical University · TWFu Jen Catholic University · TWMingDao University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor hypoxia promotes malignant progression and therapeutic resistance in glioblastoma partly by increasing the production of hydrogen peroxide (H

Indexed as

GlioblastomaGlutathione Peroxidase GPX1Cell HypoxiaCell Line, TumorEndothelial CellsHumansHydrogen PeroxideHypoxiaHypoxia-Inducible Factor 1, alpha SubunitOxidative StressGlutathione Peroxidase GPX1GPX1 protein, humanHydrogen PeroxideHypoxia-Inducible Factor 1, alpha SubunitExosomes hypoxia-inducible factorGlioblastomaGlutathione peroxidase 1Hydrogen peroxideTumor hypoxia

Identifiers

PMID37572455
PMCPMC10428075
OpenAlexW4385567213

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.