Evidence map›Paper›PMID 37572278›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Thermodynamic Characterization of Nucleic Acid Nanoparticles Hybridization by UV Melting.

Megan Teter, Ross Brumett, Abigail Coffman, Emil F Khisamutdinov

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Megan TeterChemistry Department, Ball State University, Muncie, IN, USA.
Ross BrumettChemistry Department, Ball State University, Muncie, IN, USA.
Abigail CoffmanChemistry Department, Ball State University, Muncie, IN, USA.
Emil F KhisamutdinovChemistry Department, Ball State University, Muncie, IN, USA. kemil@bsu.edu.

Funding

Nucleic Acid Nanoparticle-based Monoclonal Antibody MimicsR15EB031388 · NIBIB · BALL STATE UNIVERSITY · PI KHISAMUTDINOV, EMIL · 2021 to 2025
$1.0M
NIBIB NIH HHS R15 EB031388
6 · The paper itself

Abstract

The advances in nucleic acid nanotechnology have given rise to various elegantly designed structural complexes fabricated from DNA, RNA, chemically modified RNA strands, and their mixtures. The structural properties of NA nanoparticles (NANP) generally dictate and significantly impact biological function; and thus, it is critical to extract information regarding relative stabilities of the different structural forms. The adequate stability assessment requires knowledge of thermodynamic parameters that can be empirically derived using conventional UV-melting technique. The focus of this chapter is to describe methodology to evaluate thermodynamic data of NANPs complexation based on DNA 12 base-pair (bp) duplex formation as an example.

Indexed as

DNANucleic AcidsNucleic Acid ConformationNucleic Acid DenaturationNucleic Acid HybridizationRNAThermodynamicsDNANucleic AcidsRNADNA nanoparticlesNucleic acid hybridizationNucleic acid thermodynamicsRNA nanoparticlesUV melting

Identifiers

PMID37572278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.