Evidence map›Paper›PMID 37572277›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Preparation of Nucleic Acid Aptamer Functionalized Silver/Gold Nanoparticle Conjugates Using Thiol-Substituted Oligonucleotides.

Joshua D Quarles, Allen T Livingston, Ashley E Wood, Timea Gerczei Fernandez

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joshua D QuarlesDepartment of Chemistry, Physics, Geology and the Environment, Sims Building, Winthrop University, Rock Hill, SC, USA.
Allen T LivingstonDepartment of Chemistry, Physics, Geology and the Environment, Sims Building, Winthrop University, Rock Hill, SC, USA.
Ashley E WoodDepartment of Chemistry, Physics, Geology and the Environment, Sims Building, Winthrop University, Rock Hill, SC, USA.
Timea Gerczei FernandezDepartment of Chemistry, Physics, Geology and the Environment, Sims Building, Winthrop University, Rock Hill, SC, USA. fernandezt@winthrop.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silver and gold nanoparticle-aptamer conjugates have been extensively utilized as biosensors and microscopic vehicles that deliver a therapeutic cargo to cells. Here, we describe facile procedures to attach nucleic acid aptamers with a free thiol group to silver or gold nanoparticles. Methods to purify the nanoparticle-aptamer conjugates, verify aptamer attachment, and quantify aptamer-nanoparticle ratios are also discussed and compared. Additionally, a simple protocol that describes the aqueous synthesis of gold nanoparticles (~10 nm) is included.

Indexed as

Aptamers, NucleotideBiosensing TechniquesMetal NanoparticlesNucleic AcidsGoldOligonucleotidesSilverSulfhydryl CompoundsAptamers, NucleotideGoldNucleic AcidsOligonucleotidesSilverSulfhydryl CompoundsAptamerBiosensorConjugateGold nanoparticlesGold nanoparticle synthesisOligonucleotideSilver nanoparticlesTargeting

Identifiers

PMID37572277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.