Trial reportJournal of clinical monitoring and computing2023
Comparison of the effects of dexmedetomidine and propofol on the cardiovascular autonomic nervous system during spinal anesthesia: preliminary randomized controlled observational study.
Trial report in Journal of clinical monitoring and computing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07771101 (Association Between Early Autonomic Dysfunction Measured by the Analgesia Nociception Index), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Early Autonomic Dysfunction Measured by the Analgesia Nociception Index (ANI) and Prolonged Mechanical Ventilation in Postoperative ICU Patients
Who cites it
8 citing papers in PubMed, 4 citations in OpenAlex.
- The effect of dexmedetomidine on emergence agitation and pain in post-anesthesia recovery of patients undergoing upper limb elective orthopedic surgery: a double-blind randomized clinical trial.BMC anesthesiology · 2026Trial
- Norepinephrine prevents hypotension in older patients under spinal anesthesia with intravenous propofol sedation: a randomized controlled trial.Scientific reports · 2023Trial
- A novel index for trending sepsis and inflammatory response using processed EEG and Heart Rate Variability.Journal of clinical monitoring and computing · 2026Observational
- Looking beyond Pressure: Signal Complexity and Autonomic Physiology after Decompressive Craniectomy for Malignant Middle Cerebral Artery Infarction.Neurocritical care · 2026Article
- Autonomic Function and Cerebral Autoregulation in Children Receiving Extracorporeal Life Support.Children (Basel, Switzerland) · 2026Article
- Transient sinoatrial node dysfunction after pulsed-field pulmonary vein ablation: an image case report.Frontiers in cardiovascular medicine · 2026Article
- Differential effects of propofol and dexmedetomidine on explicit and implicit memory after sedation: a retrospective study.Frontiers in medicine · 2026Article
- Efficacy and Safety of Ciprofol for Anesthesia in Painless Colonoscopy with Varying Body Mass Indices Patients: A Prospective, Single-Center, Observational Study.Drug design, development and therapy · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal anesthesia induces sympatholysis and is usually combined with dexmedetomidine or propofol which induce different hemodynamic changes. The purpose of this study was to compare the effect on autonomic nervous system between dexmedetomidine and propofol combined with spinal anesthesia. Patients aged 20-65 undergoing elective surgery under spinal anesthesia were randomly assigned to dexmedetomidine or propofol group. Heart rate variability (HRV) and hemodynamic variables were measured at four time points: T0, baseline; T1, 10 min after spinal anesthesia; T2, 10 min after sedative administration; and T3, 20 min after sedative administration. In 59 patients, dexmedetomidine and propofol groups had significantly different hemodynamic changes over time (time × group effect P < 0.001). The dexmedetomidine group had slower heart rate at T2 (P = 0.001) and higher blood pressures at T2 and T3 (P < 0.001) than the propofol group. Overall HRV dynamics showed a significant change over time from T0 to T3, but both groups exhibited similar trends. Compared to the baseline data within the group, the low frequency (LF) decreased in both groups but the decrease occurred at T2 in the propofol group and at T3 in the dexmedetomidine group. The high frequency (HF) increased at T2 and T3 only in the dexmedetomidine group. The LF/HF ratio decreased in the dexmedetomidine group at T3. Dexmedetomidine showed slower heart rate and higher blood pressure than propofol when combined with spinal anesthesia, however, dexmedetomidine and propofol exhibited similar trends in HRV dynamics. Compared with the baseline within each group, both agents decreased LF, but only dexmedetomidine increased HF and decreased in the LF/HF ratio significantly.
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