Evidence map›Paper›PMID 37572137›Full record

ArticleInflammopharmacology2024

LC-QToF chemical profiling of Euphorbia grantii Oliv. and its potential to inhibit LPS-induced lung inflammation in rats via the NF-κB, CY450P2E1, and P38 MAPK14 pathways.

Mai Hussin Radi, Riham A El-Shiekh, Amany Mohammed Hegab, Shirley Ragae Henry, Bharathi Avula, Kumar Katragunta, Ikhlas A Khan, Ali M El-Halawany, Essam Abdel-Sattar

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Mai Hussin RadiHerbal Department, Egyptian Drug Authority (EDA), Giza, Egypt.
Riham A El-ShiekhPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Amany Mohammed HegabDevelopmental Pharmacology Department, Egyptian Drug Authority (EDA), Giza, Egypt.
Shirley Ragae HenryHistopathology Department, Egyptian Drug Authority (EDA), Giza, Egypt.
Bharathi AvulaSchool of Pharmacy, National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
Kumar KatraguntaSchool of Pharmacy, National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
Ikhlas A KhanSchool of Pharmacy, National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA.
Ali M El-HalawanyPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Essam Abdel-SattarPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. essam.abdelsattar@pharma.cu.edu.eg.ORCID http://orcid.org/0000-0002-0617-1420
Cairo University · EGEgyptian Government · EGUniversity of Mississippi · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is a life-threatening syndrome that causes high morbidity and mortality worldwide. The aerial parts of Euphorbia grantii Oliv. were extracted with methanol to give a total methanolic extract (TME), which was further fractionated into dichloromethane (DCMF) and the remaining mother liquor (MLF) fractions. Biological guided anti-inflammatory assays in vitro revealed that the DCMF showed the highest activity (IC

Indexed as

Acute Lung InjuryEuphorbiaMitogen-Activated Protein Kinase 14PneumoniaAnimalsAnti-Inflammatory AgentsLipopolysaccharidesNF-kappa BRatsAnti-Inflammatory AgentsLipopolysaccharidesMitogen-Activated Protein Kinase 14NF-kappa BAcute lung injuryAnti-inflammatoryEuphorbia grantiiIn vitro and in vivoLC-DAD-QToF chemical profilingLipopolysaccharide

Identifiers

PMID37572137
PMCPMC10907465
OpenAlexW4385781542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.