Evidence map›Paper›PMID 37571873›Full record

ArticleJournal of clinical and experimental neuropsychology2023

A comparison of diagnostic performance of word-list and story recall tests for biomarker-determined Alzheimer's disease.

Davide Bruno, Ainara Jauregi Zinkunegi, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Cynthia Carlsson, Barbara Bendlin, Ozioma Okonkwo, Nathaniel Chin, Bruce P Hermann and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of clinical and experimental neuropsychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Comorbid insomnia and sleep apnea is associated with worse verbal episodic memory in older females.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  2. A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Evaluation of Differential Diagnostics Potential of Uniform Data Set 2 Neuropsychology Battery Using Alzheimer's Disease Biomarkers.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024
    Article
  7. Predicting CDR status over 36 months with a recall-based digital cognitive biomarker.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 5 countries.

Davide BrunoSchool of Psychology, Liverpool John Moores University, UK.ORCID 0000-0003-1943-9905
Ainara Jauregi ZinkunegiSchool of Psychology, Liverpool John Moores University, UK.
Gwendlyn KollmorgenRoche Diagnostics GmbH, Penzberg, Germany.
Margherita CarboniRoche Diagnostics International Ltd, Rotkreuz, Switzerland.
Norbert WildRoche Diagnostics GmbH, Penzberg, Germany.
Cynthia CarlssonWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Barbara BendlinWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Ozioma OkonkwoWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Nathaniel ChinWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Bruce P HermannWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Sanjay AsthanaWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Rebecca LanghoughWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Sterling C JohnsonWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Nunzio PomaraGeriatric Psychiatry Division, Nathan Kline Institute, Orangeburg, NY, USA.
Henrik ZetterbergWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.
Kimberly D MuellerWisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0001-8691-9517
University of Wisconsin–Madison · USLiverpool John Moores University · GBRoche Pharma AG (Germany) · DENathan Kline Institute for Psychiatric Research · USRoche (Switzerland) · CHSahlgrenska University Hospital · SE

Funding

The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normalR01AG068398 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHIANG, GLORIA CHIA-YI · 2020 to 2024
$2.8M
Novel Story Recall Measures as Indicators of Cognitive Decline Associated with Alzheimer's Disease and Related Disorders Biomarkers: A Collaborative Study of Existing DataR01AG070940 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Kimberly D Mueller · 2021 to 2026
$2.8M
NIA NIH HHS R01 AG068398NIA NIH HHS R01 AG070940
6 · The paper itself

Abstract

backgroundWordlist and story recall tests are routinely employed in clinical practice for dementia diagnosis. In this study, our aim was to establish how well-standard clinical metrics compared to process scores derived from wordlist and story recall tests in predicting biomarker determined Alzheimer's disease, as defined by CSF ptau/Aβ42 ratio.

methodsData from 295 participants (mean age = 65 ± 9.) were drawn from the University of Wisconsin - Madison Alzheimer's Disease Research Center (ADRC) and Wisconsin Registry for Alzheimer's Prevention (WRAP). Rey's Auditory Verbal Learning Test (AVLT; wordlist) and Logical Memory Test (LMT; story) data were used. Bayesian linear regression analyses were carried out with CSF ptau/Aβ42 ratio as outcome. Sensitivity analyses were carried out with logistic regressions to assess diagnosticity.

resultsLMT generally outperformed AVLT. Notably, the best predictors were primacy ratio, a process score indexing loss of information learned early during test administration, and recency ratio, which tracks loss of recently learned information. Sensitivity analyses confirmed this conclusion.

conclusionsOur study shows that story recall tests may be better than wordlist tests for detection of dementia, especially when employing process scores alongside conventional clinical scores.

Indexed as

Alzheimer DiseaseAgedBayes TheoremBiomarkersHumansLearningMental RecallMiddle AgedBiomarkersbiomarkersdementiaMemoryserial positionstory recall

Identifiers

PMID37571873
PMCPMC10859550
OpenAlexW4385778772

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.