ArticleCancer chemotherapy and pharmacology1986
A cellular analysis of long-term haematopoietic damage in mice after repeated treatment with cyclophosphamide.
Article in Cancer chemotherapy and pharmacology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Effect of prior chemotherapy on hematopoietic stem cell mobilization.Bone marrow transplantation · 2004Article
- Continuous infusion of macrophage inflammatory protein MIP-1alpha enhances leucocyte recovery and haemopoietic progenitor cell mobilization after cyclophosphamide.British journal of cancer · 1997Article
- Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice.Infection and immunity · 1989Article
- Long-term hematopoietic damage: concepts, approaches, and results relevant to the study of environmental toxins.Environmental health perspectives · 1989Review
- Haematological recovery following high-dose cyclophosphamide with autologous bone marrow transplantation.Cancer chemotherapy and pharmacology · 1989Article
- A cellular analysis of long-term haematopoietic damage in mice after repeated treatment with cyclophosphamide.Cancer chemotherapy and pharmacology · 1986Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following repeated treatment of mice with cyclophosphamide (5 X 200 mg/kg) it was found that slight, but significant, residual marrow damage persisted for at least half the lifespan of the animals. This long-term damage occurred despite preferential sparing of those multi-potential haematopoietic cells (CFU-S) that had a high self-renewal capacity after each step of the multistep regimen and despite a smaller CFU-S kill after each successive dose. The damage was characterized by low mean numbers of CFU-S and stromal colony-forming cells (CFU-F) which were around 70% of control values. Examination of individual animals revealed that the majority had slightly subnormal numbers of CFU-S and CFU-F, with only a few suffering a more severe injury, including 8% of mice with clinical hypoplasia or myelodysplasia.
Indexed as
Identifiers
3757152What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.