Evidence map›Paper›PMID 37571336›Full record

ArticleNutrients2023

Effects of Menaquinone-7 on the Bone Health of Growing Rats under Calcium Restriction: New Insights from Microbiome-Metabolomics.

Ya Yuan, Ignatius Man-Yau Szeto, Na Li, Hua Yang, Yunzheng Zhou, Biao Liu, Fang He, Lishi Zhang, Sufang Duan, Jinyao Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Foods (Basel, Switzerland) · 2024
    Article
  4. Nutrients · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ya YuanDepartment of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Ignatius Man-Yau SzetoYili Maternal and Infant Nutrition Institute (YMINI), Inner Mongolia Yili Industrial Group, Co., Ltd., Beijing 100071, China.
Na LiDepartment of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Hua YangThe Analysis and Assay Center of Sichuan University West China School of Public Health, Sichuan University, Chengdu 610093, China.
Yunzheng ZhouDepartment of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Biao LiuYili Maternal and Infant Nutrition Institute (YMINI), Inner Mongolia Yili Industrial Group, Co., Ltd., Beijing 100071, China.
Fang HeDepartment of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-7464-5272
Lishi ZhangDepartment of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Sufang DuanYili Maternal and Infant Nutrition Institute (YMINI), Inner Mongolia Yili Industrial Group, Co., Ltd., Beijing 100071, China.ORCID 0000-0003-3093-291X
Jinyao ChenDepartment of Nutrition and Food Safety, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0003-0519-4935
Sichuan University · CNInner Mongolia Yili Industrial Group (China) · CNChengdu Medical College · CN

Funding

National Center of Technology Innovation for Dairy and Inner Mongolia Dairy Technology Research Institute.Huhhot Science & Technology Plan. No.2020-Ke Ji Xing Meng-National Innovation Center-10 project
6 · The paper itself

Abstract

Insufficient calcium intake during growth is a global public health concern. The aim of this study was to investigate the effects of dietary menaquinone-7 (MK-7) on bone accrual in growing Sprague-Dawley rats under calcium restriction. Following 13 weeks of treatment, various bone quality parameters, including microarchitecture, were measured. Fecal and cecal samples were subjected to microbiome (16S rRNA gene sequencing) analyses, while metabolomics analysis of the cecum and humerus samples was analyzed based on UHPLC-Q/TOF-MS. We found that calcium deficiency diminished the richness of the microbiome and disrupted microbiome composition, accompanied by an elevation in the relative abundance of

Indexed as

Bone and BonesBone DevelopmentCalciumGastrointestinal MicrobiomeVitamin K 2AnimalsBone DensityCecumDietary SupplementsFecesMaleMetabolomicsRatsRats, Sprague-DawleyRNA, Ribosomal, 16SCalciummenaquinone 7RNA, Ribosomal, 16SVitamin K 216s rRNA gene sequencingbone mass accumulationcalciumgrowing ratmenaquinone-7metabolomics

Identifiers

PMID37571336
PMCPMC10421271
OpenAlexW4385421776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.