Evidence map›Paper›PMID 37571327›Full record

ArticleNutrients2023

Alzheimer's Disease Genetic Influences Impact the Associations between Diet and Resting-State Functional Connectivity: A Study from the UK Biobank.

Tianqi Li, Auriel A Willette, Qian Wang, Amy Pollpeter, Brittany A Larsen, Parvin Mohammadiarvejeh, Mohammad Fili

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tianqi LiGenetics and Genomics Interdepartmental Graduate Program, Iowa State University, 1109 HNSB, 2302 Osborn Drive Ames, Ames, IA 50011, USA.ORCID 0000-0001-7215-2546
Auriel A WilletteDepartment of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Qian WangDepartment of Food Science and Human Nutrition, College of Human Sciences, Iowa State University, Ames, IA 50011, USA.
Amy PollpeterBioinformatics and Computational Biology Graduate Program, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Brittany A LarsenNeuroscience Graduate Program, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0002-6088-5176
Parvin MohammadiarvejehDepartment of Industrial and Manufacturing Systems Engineering, College of Engineering, Iowa State University, Ames, IA 50011, USA.
Mohammad FiliDepartment of Industrial and Manufacturing Systems Engineering, College of Engineering, Iowa State University, Ames, IA 50011, USA.ORCID 0000-0001-6939-4157
Iowa State University · USUniversity of Iowa · US

Funding

Insulin Resistance, Biomarkers of Brain Function, and Intermittent Calorie RestrictionR00AG047282 · NIA · IOWA STATE UNIVERSITY · PI WILLETTE, AURIEL · 2016 to 2021
$730k
NIA NIH HHS R00 AG047282NIH HHS R00 AG047282
6 · The paper itself

Abstract

backgroundRed wine and dairy products have been staples in human diets for a long period. However, the impact of red wine and dairy intake on brain network activity remains ambiguous and requires further investigation.

methodsThis study investigated the associations between dairy and red wine consumption and seven neural networks' connectivity with functional magnetic resonance imaging (fMRI) data from a sub-cohort of the UK Biobank database. Linear mixed models were employed to regress dairy and red wine consumption against the intrinsic functional connectivity for each neural network. Interactions with Alzheimer's disease (AD) risk factors, including apolipoprotein E4 (APOE4) genotype, TOMM40 genotype, and family history of AD, were also assessed.

resultMore red wine consumption was associated with enhanced connectivity in the central executive function network and posterior default mode network. Greater milk intake was correlated with more left executive function network connectivity, while higher cheese consumption was linked to reduced posterior default mode network connectivity. For participants without a family history of Alzheimer's disease (AD), increased red wine consumption was positively correlated with enhanced left executive function network connectivity. In contrast, participants with a family history of AD displayed diminished network connectivity in relation to their red wine consumption. The association between cheese consumption and neural network connectivity was influenced by APOE4 status, TOMM40 status, and family history, exhibiting contrasting patterns across different subgroups.

conclusionThe findings of this study indicate that family history modifies the relationship between red wine consumption and network strength. The interaction effects between cheese intake and network connectivity may vary depending on the presence of different genetic factors.

Indexed as

Alzheimer DiseaseApolipoprotein E4Biological Specimen BanksBrainDietHumansMagnetic Resonance ImagingUnited KingdomApolipoprotein E4Alzheimer’s diseasedairy consumptionfMRIneural network connectivityred wine consumption

Identifiers

PMID37571327
PMCPMC10420831
OpenAlexW4385421654

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.