Palladated Cyclodextrin Nanosponge-Alginate Dual Bead as an Efficient Catalyst for Hydrogenation of Nitroarenes in Aqueous Solution.

In this study, we present a novel composite material consisting of β-cyclodextrin nanosponge and sodium alginate, used as a support for the immobilization of palladium (Pd) nanoparticles. The composite alginate-cyclodextrin nanosponge beads were prepared, taking advantage of the 3D polymeric network and β-cyclodextrin cavity of the nanosponge. These beads exhibited excellent encapsulation capabilities for hydrophobic substrates, allowing their transfer in aqueous media. The cyclodextrin nanosponge served as a stabilizer for Pd nanoparticles and facilitated phase transfer. Additionally, the sodium alginate bead contributed to the robustness of the structure and improved the recovery and recyclability of the composite material. Comparative studies with control catalysts confirmed the beneficial effect of incorporating cyclodextrin nanosponge within alginate beads, particularly for more hydrophobic substrates. Optimization of reaction conditions revealed that employing 0.03 g of catalyst per mmol of nitroarene at 45 °C resulted in the maximum yield within 90 min. Evaluation of the substrate scope demonstrated the hydrogenation capability of various substrates with different electronic properties under the developed protocol. Notably, the nitro group was selectively reduced in substrates featuring competing functionalities. Furthermore, the recyclability and stability of the composite catalyst were confirmed, making it a promising candidate for sustainable catalysis.