Evidence map›Paper›PMID 37570729›Full record

ArticleMolecules (Basel, Switzerland)2023

Nickel Nanoparticles Induced Hepatotoxicity in Mice via Lipid-Metabolism-Dysfunction-Regulated Inflammatory Injury.

Shuang Zhou, Hua Li, Hui Wang, Rui Wang, Wei Song, Da Li, Changlei Wei, Yu Guo, Xueying He, Yulin Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shuang ZhouBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Hua LiBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Hui WangBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Rui WangBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Wei SongBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Da LiBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Changlei WeiBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Yu GuoBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Xueying HeBeijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment, Beijing 101111, China.
Yulin DengBeijing Institute of Technology, School of Life Science, Beijing 100081, China.ORCID 0000-0002-0720-4052
Beijing Institute of Technology · CN

Funding

Scientific Development Research Project of Beijing Institute of Medical Device Testing, Beijing Center for Testing and Research of Medical Biological Protective Equipment KFXM-001-2022
6 · The paper itself

Abstract

Nickel nanoparticles (NiNPs) have wide applications in industry and biomedicine due to their unique characteristics. The liver is the major organ responsible for nutrient metabolism, exogenous substance detoxification and biotransformation of medicines containing nanoparticles. Hence, it is urgent to further understand the principles and potential mechanisms of hepatic effects on NiNPs administration. In this study, we explored the liver impacts in male C57/BL6 mice through intraperitoneal injection with NiNPs at doses of 10, 20 and 40 mg/kg/day for 7 and 28 days. The results showed that NiNPs treatment increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and induced pathological changes in liver tissues. Moreover, hepatic triglyceride (TG) content and lipid droplet deposition identified via

Indexed as

Chemical and Drug Induced Liver InjuryNanoparticlesAnimalsEndoplasmic Reticulum StressEndoribonucleasesLipid MetabolismLiverMaleMiceMice, Inbred C57BLNickelProtein Serine-Threonine KinasesTriglyceridesEndoribonucleasesNickelProtein Serine-Threonine KinasesTriglycerideshepatic inflammationhepatotoxicitynickel nanoparticlessteatosis

Identifiers

PMID37570729
PMCPMC10421287
OpenAlexW4385421716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.