Evidence map›Paper›PMID 37570684›Full record

ArticleMolecules (Basel, Switzerland)2023

Pyronaridine as a Bromodomain-Containing Protein 4-

Mahmoud A A Ibrahim, Mahmoud M H Abdelhamid, Khlood A A Abdeljawaad, Alaa H M Abdelrahman, Gamal A H Mekhemer, Peter A Sidhom, Shaban R M Sayed, Paul W Paré, Mohamed-Elamir F Hegazy, Tamer Shoeib

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Journal of tropical medicine · 2025
    Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Mahmoud A A IbrahimComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0003-4819-2040
Mahmoud M H AbdelhamidComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0009-0006-8582-9759
Khlood A A AbdeljawaadComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0001-8667-664X
Alaa H M AbdelrahmanComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0003-3527-0126
Gamal A H MekhemerComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0003-2474-076X
Peter A SidhomDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.ORCID 0000-0003-2579-6351
Shaban R M SayedDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Paul W ParéDepartment of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0003-1644-723X
Mohamed-Elamir F HegazyChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.ORCID 0000-0002-0343-4969
Tamer ShoeibDepartment of Chemistry, The American University in Cairo, New Cairo 11835, Egypt.ORCID 0000-0003-3512-1593
Minia University · EGAmerican University in Cairo · EGKing Saud University · SANational Research Centre · EGTanta University · EGTexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRD4 (bromodomain-containing protein 4) is an epigenetic reader that realizes histone proteins and promotes the transcription of genes linked to cancer progression and non-cancer diseases such as acute heart failure and severe inflammation. The highly conserved

Indexed as

Molecular Dynamics SimulationNuclear ProteinsBromodomain Containing ProteinsCell Cycle ProteinsLigandsMolecular Docking SimulationNaphthyridinesTranscription FactorsBromodomain Containing ProteinsCell Cycle ProteinsLigandsNaphthyridinesNuclear ProteinspyronaridineTranscription Factorsbromodomain-containing protein 4cancer diseasemolecular dockingmolecular dynamics simulationsSuperDRUG2 database

Identifiers

PMID37570684
PMCPMC10420099
OpenAlexW4385342637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.