Evidence map›Paper›PMID 37570610›Full record

ReviewMolecules (Basel, Switzerland)2023

Phosphatidylcholine-Specific Phospholipase C as a Promising Drug Target.

Chatchakorn Eurtivong, Euphemia Leung, Nabangshu Sharma, Ivanhoe K H Leung, Jóhannes Reynisson

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. The role of phosphatidylcholine metabolism in tumors.Medical oncology (Northwood, London, England) · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Exploring the Genomic Landscape ofCurrent issues in molecular biology · 2024
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Chatchakorn EurtivongDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Si Ayutthaya Road, Ratchathewi, Bangkok 10400, Thailand.
Euphemia LeungAuckland Cancer Society Research Centre, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Nabangshu SharmaSchool of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Ivanhoe K H LeungSchool of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Rd, Parkville, VIC 3052, Australia.ORCID 0000-0003-0633-6771
Jóhannes ReynissonSchool of Pharmacy and Bioengineering, Keele University, Newcastle-under-Lyme ST5 5BG, UK.ORCID 0000-0003-4174-9512
Keele University · GBMahidol University · THMuseum of New Zealand Te Papa Tongarewa · NZThe University of Melbourne · AUUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphatidylcholine-specific phospholipase C (PC-PLC) is an enzyme that catalyzes the formation of the important secondary messengers phosphocholine and diacylglycerol (DAG) from phosphatidylcholine. Although PC-PLC has been linked to the progression of many pathological conditions, including cancer, atherosclerosis, inflammation and neuronal cell death, studies of PC-PLC on the protein level have been somewhat neglected with relatively scarce data. To date, the human gene expressing PC-PLC has not yet been found, and the only protein structure of PC-PLC that has been solved was from

Indexed as

PhosphatidylcholinesType C PhospholipasesHumansPhosphatidylcholinesphosphatidylcholine-specific phospholipase CType C Phospholipasesatherosclerosiscancerdrug discoveryinflammationinhibitors

Identifiers

PMID37570610
PMCPMC10420013
OpenAlexW4385278371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.