Evidence map›Paper›PMID 37570507›Full record

ArticleNanomaterials (Basel, Switzerland)2023

Role of Chemical Reduction and Formulation of Graphene Oxide on Its Cytotoxicity towards Human Epithelial Bronchial Cells.

Marco Pelin, Clara Passerino, Adriana Rodríguez-Garraus, Michela Carlin, Silvio Sosa, Satu Suhonen, Gerard Vales, Beatriz Alonso, Amaia Zurutuza, Julia Catalán and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Marco PelinDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.ORCID 0000-0002-4306-7411
Clara PasserinoDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.
Adriana Rodríguez-GarrausFinnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, Finland.
Michela CarlinDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.
Silvio SosaDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.ORCID 0000-0002-2909-6603
Satu SuhonenFinnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, Finland.
Gerard ValesFinnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, Finland.
Beatriz AlonsoGraphenea S.A., Mikeletegi 83, 20009 San Sebastián, Spain.ORCID 0000-0002-6282-2670
Amaia ZurutuzaGraphenea S.A., Mikeletegi 83, 20009 San Sebastián, Spain.ORCID 0000-0001-6376-0224
Julia CatalánFinnish Institute of Occupational Health, Box 40, Työterveyslaitos, 00032 Helsinki, Finland.ORCID 0000-0003-2936-242X
Aurelia TubaroDepartment of Life Sciences, University of Trieste, Via Fleming 22, 34127 Trieste, Italy.
University of Trieste · ITFinnish Institute of Occupational Health · FIGraphenea (Spain) · ESUniversidad de Zaragoza · ES

Funding

Finnish Work Environment Fund GrapHazard ProjectIstituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro GrapHazard Project
6 · The paper itself

Abstract

Graphene-based materials may pose a potential risk for human health due to occupational exposure, mainly by inhalation. This study was carried out on bronchial epithelial 16HBE14o- cells to evaluate the role of chemical reduction and formulation of graphene oxide (GO) on its cytotoxic potential. To this end, the effects of GO were compared to its chemically reduced form (rGO) and its stable water dispersion (wdGO), by means of cell viability reduction, reactive oxygen species (ROS) generation, pro-inflammatory mediators release and genotoxicity. These materials induced a concentration-dependent cell viability reduction with the following potency rank: rGO > GO >> wdGO. After 24 h exposure, rGO reduced cell viability with an EC

Indexed as

cytotoxicitygraphene-based materialsgraphene oxidehazard characterizationinhalational exposureoccupational exposurephysicochemical propertiesreduced graphene oxidesafety assessment

Identifiers

PMID37570507
PMCPMC10420834
OpenAlexW4385349224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.