Evidence map›Paper›PMID 37569732›Full record

ArticleInternational journal of molecular sciences2023

Analysis of Novel Immunological Biomarkers Related to Rheumatoid Arthritis Disease Severity.

Sandra Pascual-García, Pascual Martínez-Peinado, Ana B López-Jaén, Francisco J Navarro-Blasco, Yoel G Montoyo-Pujol, Enrique Roche, Gloria Peiró, José M Sempere-Ortells

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sandra Pascual-GarcíaDepartment of Biotechnology, University of Alicante, 03690 San Vicente del Raspeig, Spain.ORCID 0000-0002-0536-1185
Pascual Martínez-PeinadoDepartment of Biotechnology, University of Alicante, 03690 San Vicente del Raspeig, Spain.ORCID 0000-0003-4370-5468
Ana B López-JaénDepartment of Biotechnology, University of Alicante, 03690 San Vicente del Raspeig, Spain.
Francisco J Navarro-BlascoDepartment of Biotechnology, University of Alicante, 03690 San Vicente del Raspeig, Spain.
Yoel G Montoyo-PujolMedical Oncology Department, Dr. Balmis University General Hospital, Pintor Baeza 12, 03010 Alicante, Spain.ORCID 0000-0003-3169-0924
Enrique RocheBiochemistry and Cell Therapy Unit, Institute of Bioengineering, Miguel Hernandez University of Elche, 03202 Elche, Spain.ORCID 0000-0001-5128-1672
Gloria PeiróDepartment of Biotechnology, University of Alicante, 03690 San Vicente del Raspeig, Spain.
José M Sempere-OrtellsDepartment of Biotechnology, University of Alicante, 03690 San Vicente del Raspeig, Spain.
University of Alicante · ESHospital General Universitario de Alicante Doctor Balmis · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

Spanish Ministry of Education FPU14/01984University of Alicante Doctoral School of the University of AlicanteUniversity of Alicante GRE17-07
6 · The paper itself

Abstract

Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs) are the most frequently used rheumatoid arthritis (RA) diagnostic markers, but they are unable to anticipate the patient's evolution or response to treatment. The aim of this study was to identify possible severity biomarkers to predict an upcoming flare-up or remission period. To address this objective, sera and anticoagulated blood samples were collected from healthy controls (HCs; n = 39) and from early RA (n = 10), flare-up (n = 5), and remission (n = 16) patients. We analyzed leukocyte phenotype markers, regulatory T cells, cell proliferation, and cytokine profiles. Flare-up patients showed increased percentages of cluster of differentiation (CD)3

Indexed as

Arthritis, RheumatoidBiomarkersAdultAgedCase-Control StudiesCytokinesFemaleHumansMaleMiddle AgedROC CurveSeverity of Illness IndexT-Lymphocytes, RegulatoryBiomarkersCytokinesbiomarkersB lymphocytescentral memory cellscytotoxic T lymphocytesdisease severityeffector memory cellsleukocyte phenotypeNK/T lymphocyte ratiorheumatoid arthritis

Identifiers

PMID37569732
PMCPMC10418816
OpenAlexW4385491433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.