ReviewInternational journal of molecular sciences2023
Local Thyroid Hormone Action in Brain Development.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Thyrotropin levels in first-episode bipolar disorder and their association with clinical phenotypes: systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Association of overt hypothyroidism with risks of cognitive impairment: a meta-analysis and systematic review.Frontiers in endocrinology · 2025Pooled it
- An ASXL3-thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors.Science advances · 2026Article
- Thyroxine Disrupts Synaptic Plasticity via Non-genomic Action in the Hippocampus.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Beyond Hormone Levels: Thyroid Hormone Signaling from Neurogenesis to Alzheimer's Disease.Cells · 2026Review
- Developmental neurotoxicity of thyroid hormone system-disrupting chemicals: a systems-level exploration using multi-omics approach.Archives of toxicology · 2026Article
- Thyroid hormone regulatory system in the mouse retina: integrated transcriptional and translational analysis of deiodinase enzymes, thyroid hormone receptors and thyroid hormone transporters.Cell communication and signaling : CCS · 2026Article
- Trajectories of growth and language development among children with congenital hypothyroidism concerning gender differences: Egyptian study.BMC pediatrics · 2026Article
- Sex-specific associations between thyroid hormones and the severity of positive and negative symptoms in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Aescin and rutin mitigate hyperthyroidism-induced multisystem dysfunction via antioxidant and anti-inflammatory mechanisms in a rat model.Scientific reports · 2026Article
- Emerging Roles, Mechanisms, and Therapeutic Potential of Thyroid Hormones in Neurodegenerative Diseases: A Review.Brain sciences · 2026Review
- The Association of Thyroid Function on Cognition and Neuropsychiatric Symptoms in Patients with Cognitive Impairment.Neuropsychiatric disease and treatment · 2026Article
- Neuron-specific expression of murine thyroid hormone transporters Mct8 and Oatp1c1 is dispensable for hippocampus-dependent neuronal functions.Frontiers in endocrinology · 2026Article
- Developmental neurotoxicity of organophosphate flame retardants (OPFRs): risks to human health and ecosystems.Archives of toxicology · 2025Review
- Assessment of the association of high-iodine exposure in drinking water, iodine intake, and thyroid function in 3-14-year-old children.Scientific reports · 2025Article
- Review
- Disease duration-stratified associations of thyroid hormone levels with psychopathology in hospitalized patients with schizophrenia: A cross-sectional study.World journal of psychiatry · 2025Article
- Trisomy 21 Disrupts Thyroid Hormones Signaling During Human iPSC-Derived Neural Differentiation In Vitro.Cells · 2025Article
- Key Messages of the Iodine Deficiency Working Group (AKJ): Maternal Hypothyroxinemia Due to Iodine Deficiency and Endocrine Disruptors as Risks for Child Neurocognitive Development.Geburtshilfe und Frauenheilkunde · 2025Article
- Developmental neurotoxicity of bisphenol F and bisphenol S in animal model systems: A literature review.Neurotoxicology · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Proper brain development essentially depends on the timed availability of sufficient amounts of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH signaling components such as TH transporters, deiodinases, and TH receptors in a brain region- and cell-specific manner from early developmental stages onwards. Abnormal TH levels during critical stages, as well as mutations in TH signaling components that alter the global and/or local thyroidal state, result in detrimental consequences for brain development and neurological functions that involve alterations in central neurotransmitter systems. Thus, the question as to how TH signaling is implicated in the development and maturation of different neurotransmitter and neuromodulator systems has gained increasing attention. In this review, we first summarize the current knowledge on the regulation of TH signaling components during brain development. We then present recent advances in our understanding on how altered TH signaling compromises the development of cortical glutamatergic neurons, inhibitory GABAergic interneurons, cholinergic and dopaminergic neurons. Thereby, we highlight novel mechanistic insights and point out open questions in this evolving research field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.