Evidence map›Paper›PMID 37569694›Full record

ArticleInternational journal of molecular sciences2023

Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children.

Jihoon Kim, Chisato Shimizu, Ming He, Hao Wang, Hal M Hoffman, Adriana H Tremoulet, John Y-J Shyy, Jane C Burns

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Plasma cell-free RNA signatures of inflammatory syndromes in children.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jihoon KimDepartment of Biomedical Informatics, University of California, San Diego, CA 92093, USA.
Chisato ShimizuDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.
Ming HeDepartment of Medicine, University of California, San Diego, CA 92093, USA.
Hao WangDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-1518-9702
Hal M HoffmanDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.
Adriana H TremouletDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.
John Y-J ShyyDepartment of Medicine, University of California, San Diego, CA 92093, USA.
Jane C BurnsDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.
University of California San Diego · USYale University · US

Funding

Innate Immune Activation and Endothelial Cell Dysfunction in Acute Kawasaki DiseaseR01HL140898 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C, HOFFMAN, HAROLD M · 2018 to 2022
$4.3M
Diagnosing and predicting risk in children with SARS-CoV-2- related illnessR33HD105590 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BURNS, JANE C · 2023 to 2023
$2.9M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NHLBI NIH HHS R01 HL140898NICHD NIH HHS R33 HD105590NIH HHS R01HL140898, S10 OD026929NIH HHS S10 OD026929
6 · The paper itself

Abstract

Although Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) share some clinical manifestations, their cardiovascular outcomes are different, and this may be reflected at the level of the endothelial cell (EC). We performed RNA-seq on cultured ECs incubated with pre-treatment sera from KD (

Indexed as

Connective Tissue DiseasesCOVID-19Mucocutaneous Lymph Node SyndromeChildEndothelial CellsHumansSystemic Inflammatory Response SyndromeapoptosisautophagyEndoMTendothelial cellKawasaki diseaseMIS-Cnetwork analysisNFκB pathwayRNA-seqWGCNA

Identifiers

PMID37569694
PMCPMC10418493
OpenAlexW4385445427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.