Evidence map›Paper›PMID 37569650›Full record

ArticleInternational journal of molecular sciences2023

Serum NMR-Based Metabolomics Profiling Identifies Lipoprotein Subfraction Variables and Amino Acid Reshuffling in Myeloma Development and Progression.

Shona Pedersen, Morten Faarbæk Mikkelstrup, Søren Risom Kristensen, Najeha Rizwana Anwardeen, Mohamed A Elrayess, Trygve Andreassen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. [Progress in metabolomics of multiple myeloma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Shona PedersenCollege of Medicine, QU Health, Qatar University, Doha 2713, Qatar.ORCID 0000-0001-6636-0293
Morten Faarbæk MikkelstrupDepartment of Health Science and Technology, Aalborg University, DK-9220 Aalborg, Denmark.
Søren Risom KristensenDepartment of Clinical Biochemistry, Aalborg University Hospital, DK-9000 Aalborg, Denmark.ORCID 0000-0002-2649-506X
Najeha Rizwana AnwardeenBiomedical Research Center (BRC), Qatar University, Doha 2713, Qatar.ORCID 0000-0002-7263-4905
Mohamed A ElrayessBiomedical Research Center (BRC), Qatar University, Doha 2713, Qatar.ORCID 0000-0003-3803-4604
Trygve AndreassenDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
Qatar University · QAAalborg University · DKAalborg University Hospital · DKNorwegian University of Science and Technology · NO

Funding

Danish Research Council for Independent Research 4183-00268Obel Family Foundation 26145
6 · The paper itself

Abstract

Multiple myeloma (MM) is an incurable hematological cancer. It is preceded by monoclonal gammopathy of uncertain significance (MGUS)-an asymptomatic phase. It has been demonstrated that early detection increases the 5-year survival rate. However, blood-based biomarkers that enable early disease detection are lacking. Metabolomic and lipoprotein subfraction variable profiling is gaining traction to expand our understanding of disease states and, more specifically, for identifying diagnostic markers in patients with hematological cancers. This study aims to enhance our understanding of multiple myeloma (MM) and identify candidate metabolites, allowing for a more effective preventative treatment. Serum was collected from 25 healthy controls, 20 patients with MGUS, and 30 patients with MM.

Indexed as

Amino AcidsLipoproteinsMetabolomicsMultiple MyelomaAdultAgedBiomarkers, TumorCase-Control StudiesDisease ProgressionFemaleHumansMagnetic Resonance SpectroscopyMaleMetabolomeMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceAmino AcidsBiomarkers, TumorLipoproteinsmonoclonal gammopathy of undetermined significancemultiple myelomamultivariate analysisNuclear Magnetic Resonancepathway analysisserum diagnostic metabolitesunivariate analysis

Identifiers

PMID37569650
PMCPMC10419104
OpenAlexW4385455950

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.