ArticleInternational journal of molecular sciences2023
A Novel Mechanism for Bone Loss: Platelet Count Negatively Correlates with Bone Mineral Density via Megakaryocyte-Derived RANKL.
Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Retrospective cross-sectional associations of whole blood cell count and hemoglobin level with lumbar bone mineral density in older adults.The Journal of international medical research · 2026Article
- Case report: A case of ITP-like thrombocytopenia induced by denosumab.Frontiers in pharmacology · 2026Article
- Complete Blood Count Parameters and Bone Health: Clinical and Experimental Evidence.Endocrinology and metabolism (Seoul, Korea) · 2025Review
- RANKL/OPG Axis and Bone Mineral Density in Pediatric Inflammatory Bowel Disease.Journal of clinical medicine · 2025Article
- Sex-specific association between platelet content and bone mineral density in adults: a cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Pathological progression of osteoarthritis: a perspective on subchondral bone.Frontiers of medicine · 2024Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
A potential association between hematopoietic stem cell status in bone marrow and surrounding bone tissue has been hypothesized, and some studies have investigated the link between blood count and bone mineral density (BMD), although their exact relationship remains controversial. Moreover, biological factors linking the two are largely unknown. In our present study, we found no clear association between platelet count and BMD in the female group, with aging having a very strong effect on BMD. On the other hand, a significant negative correlation was found between platelet count and BMD in the male group. As a potential mechanism, we examined whether megakaryocytes, the source of platelet production, secrete cytokines that regulate BMD, namely OPG, M-CSF, and RANKL. We detected the production of these cytokines by megakaryocytes derived from bone marrow mononuclear cells, and found that RANKL was negatively correlated with BMD. This finding suggests that RANKL production by megakaryocytes may mediate the negative correlation between platelet count and BMD. To our knowledge, this is the first report to analyze bone marrow cells as a mechanism for the association between blood count and BMD. Our study may provide new insights into the development and potential treatment of osteoporosis.
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Registered trials
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