Evidence map›Paper›PMID 37569513›Full record

ArticleInternational journal of molecular sciences2023

Modified Lactoperoxidase System as a Promising Anticaries Agent: In Vitro Studies on

Marcin Magacz, Sergio Alatorre-Santamaría, Karolina Kędziora, Kacper Klasa, Paweł Mamica, Wiktoria Pepasińska, Magdalena Lebiecka, Dorota Kościelniak, Elżbieta Pamuła, Wirginia Krzyściak

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Marcin MagaczDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0001-7677-8562
Sergio Alatorre-SantamaríaDepartment of Biotechnology, Biological Science Division, Autonomous Metropolitan University, San Rafael Atlixco 186, Mexico City 09310, Mexico.ORCID 0000-0001-6251-7855
Karolina KędzioraDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Kacper KlasaDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.ORCID 0009-0007-2123-9968
Paweł MamicaDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Wiktoria PepasińskaDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Magdalena LebieckaDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Dorota KościelniakDepartment of Pediatric Dentistry, Institute of Dentistry, Jagiellonian University Medical College, Montelupich 4, 31-155 Krakow, Poland.
Elżbieta PamułaDepartment of Biomaterials and Composites, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, Poland.
Wirginia KrzyściakDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Jagiellonian University · PLAGH University of Krakow · PLUniversidad Autónoma Metropolitana · MX

Funding

National Science Center 2021/41/N/NZ7/03315
6 · The paper itself

Abstract

The lactoperoxidase (LPO) system shows promise in the prevention of dental caries, a common chronic disease. This system has antimicrobial properties and is part of the non-specific antimicrobial immune system. Understanding the efficacy of the LPO system in the fight against biofilms could provide information on alternative strategies for the prevention and treatment of caries. In this study, the enzymatic system was modified using four different (pseudo)halide substrates (thiocyanate, thiocyanate-iodide mixture, selenocyanate, and iodide). The study evaluated the metabolic effects of applying such modifications to

Indexed as

Anti-Infective AgentsDental CariesBiofilmsCyanatesGlucoseHumansIodidesLactatesLactoperoxidaseNADSelenium CompoundsStreptococcus mutansThiocyanatesAnti-Infective AgentsCyanatesGlucoseIodidesLactatesLactoperoxidaseNADSelenium Compoundsselenocyanic acidThiocyanatesbiofilmcariogenic biofilmdental carieslactoperoxidaselactoperoxidase system modulatorsStreptococcus mutans

Identifiers

PMID37569513
PMCPMC10418824
OpenAlexW4385399899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.