Evidence map›Paper›PMID 37569479›Full record

ReviewInternational journal of molecular sciences2023

T-Cell Prolymphocytic Leukemia: Diagnosis, Pathogenesis, and Treatment.

Marc Gutierrez, Patrick Bladek, Busra Goksu, Carlos Murga-Zamalloa, Dale Bixby, Ryan Wilcox

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marc GutierrezDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7329-0462
Patrick BladekDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.
Busra GoksuDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.
Carlos Murga-ZamalloaDepartment of Pathology, University of Illinois Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2238-5066
Dale BixbyDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 60607, USA.
Ryan WilcoxDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI 60607, USA.ORCID 0000-0002-6420-0760
University of Illinois Chicago · USUniversity of Michigan · US

Funding

Pacritinib in rel/refr T-cell lymphomasR01CA265929 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILCOX, RYAN A · 2021 to 2025
$3.2M
THE T-CELL RECEPTOR'S ROLE IN T-CELL LYMPHOMA PATHOGENESISR37CA233476 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILCOX, RYAN A · 2019 to 2025
$2.2M
Notch and GATA-3 as novel therapeutic targets in T-cell lymphomasR01CA236722 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILCOX, RYAN A · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA236722NCI NIH HHS R01 CA265929NCI NIH HHS R37 CA233476NIH HHS R01CA236722NIH HHS R01CA265929NIH HHS R37CA233476
6 · The paper itself

Abstract

T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells. Most patients with T-PLL present with lymphocytosis, anemia, thrombocytopenia, and hepatosplenomegaly. Correct identification of T-PLL is essential because treatment for this disease is distinct from that of other T-cell neoplasms. In 2019, the T-PLL International Study Group (TPLL-ISG) established criteria for the diagnosis, staging, and assessment of response to treatment of T-PLL with the goal of harmonizing research efforts and supporting clinical decision-making. T-PLL pathogenesis is commonly driven by T-cell leukemia 1 (

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Prolymphocytic, T-CellAlemtuzumabHumansMutationAlemtuzumabalemtuzumabATMBH3 mimeticJAKSTATT-cell receptorTCL1AT-prolymphocytic leukemia (T-PLL)

Identifiers

PMID37569479
PMCPMC10419310
OpenAlexW4385349654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.