Evidence map›Paper›PMID 37569478›Full record

ArticleInternational journal of molecular sciences2023

NMR-Chemical-Shift-Driven Protocol Reveals the Cofactor-Bound, Complete Structure of Dynamic Intermediates of the Catalytic Cycle of Oncogenic KRAS G12C Protein and the Significance of the Mg

Márton Gadanecz, Zsolt Fazekas, Gyula Pálfy, Dóra Karancsiné Menyhárd, András Perczel

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Márton GadaneczLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/A, H-1117 Budapest, Hungary.ORCID 0009-0009-8076-7597
Zsolt FazekasLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/A, H-1117 Budapest, Hungary.ORCID 0000-0001-5007-4807
Gyula PálfyLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/A, H-1117 Budapest, Hungary.ORCID 0000-0003-1590-5331
Dóra Karancsiné MenyhárdLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/A, H-1117 Budapest, Hungary.ORCID 0000-0002-0095-5531
András PerczelLaboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter stny. 1/A, H-1117 Budapest, Hungary.

Funding

European Union and the State of Hungary, co-financed by the European Regional Devel-opment Fund GINOP-2.3.3-15-2016-00004European Union and the State of Hungary, co-financed by the European Regional Devel-opment Fund VEKOP-2.3.2-16-2017-00014European Union's Recovery and Resilience Instrument RRF-2.3.1-21-2022-00015Horizon 2020 program of the European Commission iNEXT 653706Ministry for Innovation and Technology from the Hungarian NRDI Fund 2020-1.1.6-JÖVŐ-2021-00010National Research Development and Innovation Fund of Hungary 2018-1.2.1-NKP-2018-00005the European Union and the State of Hungary, co-financed by the European Regional De-velopment Fund VEKOP-2.3.3-15-2017-00018
6 · The paper itself

Abstract

In this work, catalytically significant states of the oncogenic G12C variant of KRAS, those of Mg

Indexed as

Magnetic Resonance ImagingProto-Oncogene Proteins p21(ras)Magnetic Resonance SpectroscopyMolecular Dynamics SimulationMutationProto-Oncogene Proteins p21(ras)KRASligand bindingmolecular dynamics simulationNMR spectroscopyprotein dynamicsprotein structure determination

Identifiers

PMID37569478
PMCPMC10418480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.