Evidence map›Paper›PMID 37569398›Full record

ArticleInternational journal of molecular sciences2023

The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2.

Said Assou, Engi Ahmed, Lisa Morichon, Amel Nasri, Florent Foisset, Carine Bourdais, Nathalie Gros, Sonia Tieo, Aurelie Petit, Isabelle Vachier and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  14. The Immune Response ofInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Said AssouIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0000-0001-6448-7995
Engi AhmedIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0000-0001-9498-8985
Lisa MorichonIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0000-0003-2146-1837
Amel NasriIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0009-0007-4639-2459
Florent FoissetIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0009-0001-4577-5155
Carine BourdaisIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0009-0004-3375-2409
Nathalie GrosCEMIPAI, Université de Montpellier, CNRS UAR3725, 34090 Montpellier, France.
Sonia TieoCEFE, University of Montpellier, CNRS, EPHE, IRD, 34090 Montpellier, France.
Aurelie PetitDepartment of Respiratory Diseases, CHU Montpellier, Arnaud de Villeneuve Hospital, INSERM, 34000 Montpellier, France.ORCID 0000-0002-9069-9868
Isabelle VachierDepartment of Respiratory Diseases, CHU Montpellier, Arnaud de Villeneuve Hospital, INSERM, 34000 Montpellier, France.ORCID 0000-0003-2730-5165
Delphine MuriauxCEMIPAI, Université de Montpellier, CNRS UAR3725, 34090 Montpellier, France.
Arnaud BourdinDepartment of Respiratory Diseases, CHU Montpellier, Arnaud de Villeneuve Hospital, INSERM, 34000 Montpellier, France.
John De VosIRMB, University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.ORCID 0000-0003-1880-4130
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Airway-liquid interface cultures of primary epithelial cells and of induced pluripotent stem-cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant models for respiratory virus infection studies because they can mimic the in vivo human bronchial epithelium. Here, we investigated gene expression profiles in human airway cultures (ALI and iALI models), infected or not with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), using our own and publicly available bulk and single-cell transcriptome datasets. SARS-CoV-2 infection significantly increased the expression of interferon-stimulated genes (

Indexed as

COVID-19SARS-CoV-2Epithelial CellsEpitheliumHumansInterferonsRespiratory MucosaTranscriptomeInterferonsairway in vitro modelsiPS cellsSARS-CoV-2 signaturestranscriptomic analysis

Identifiers

PMID37569398
PMCPMC10418806
OpenAlexW4385347455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.