Evidence map›Paper›PMID 37569329›Full record

ArticleInternational journal of molecular sciences2023

A Genetically Engineered Bivalent Vaccine Coexpressing a Molecular Adjuvant against Classical Swine Fever and Porcine Epidemic Diarrhea.

Hao Wang, Weicheng Yi, Huan Qin, Qin Wang, Rui Guo, Zishu Pan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hao WangState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Weicheng YiState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Huan QinState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Qin WangWorld Organization for Animal Health Reference Laboratory for Classical Swine Fever, China Institute of Veterinary Drug Control, Beijing 100081, China.
Rui GuoKey Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan 430064, China.
Zishu PanState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Wuhan University · CNChina Institute of Veterinary Drug Control · CNMinistry of Agriculture and Rural Affairs · CN

Funding

National Natural Science Foundation of China 31570152National Natural Science Foundation of China 31670154
6 · The paper itself

Abstract

Classical swine fever (CSF) and porcine epidemic diarrhea (PED) are highly contagious viral diseases that pose a significant threat to piglets and cause substantial economic losses in the global swine industry. Therefore, the development of a bivalent vaccine capable of targeting both CSF and PED simultaneously is crucial. In this study, we genetically engineered a recombinant classical swine fever virus (rCSFV) expressing the antigenic domains of the porcine epidemic diarrhea virus (PEDV) based on the modified infectious cDNA clone of the vaccine strain C-strain. The S1N and COE domains of PEDV were inserted into C-strain cDNA clone harboring the mutated 136th residue of N

Indexed as

Classical Swine FeverCoronavirus InfectionsSwine DiseasesViral VaccinesAdjuvants, ImmunologicAdjuvants, PharmaceuticAnimalsAntibodies, ViralDiarrheaDNA, ComplementaryRabbitsSwineTissue Plasminogen ActivatorVaccines, CombinedAdjuvants, ImmunologicAdjuvants, PharmaceuticAntibodies, ViralDNA, ComplementaryTissue Plasminogen ActivatorVaccines, CombinedViral Vaccinesbivalent vaccineclassical swine fever virusmolecular adjuvantporcine epidemic diarrhea virusVISA

Identifiers

PMID37569329
PMCPMC10419043
OpenAlexW4385310103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.