Evidence map›Paper›PMID 37569282›Full record

ArticleInternational journal of molecular sciences2023

Proteomic Analysis of Dysfunctional Liver Sinusoidal Endothelial Cells Reveals Substantial Differences in Most Common Experimental Models of Chronic Liver Diseases.

Mar Gil, Mikel Azkargorta, Carla Fuster, María Martínez-Gómez, Imma Raurell, Aurora Barberá, Juan Manuel Pericàs, Diana Hide, Felix Elortza, Joan Genescà and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mar GilLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
Mikel AzkargortaProteomics Platform, CIC bioGUNE, BRTA (Basque Research & Technology Alliance), Bizkaia Science and Technology Park, 48160 Derio, Spain.
Carla FusterLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
María Martínez-GómezLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.ORCID 0009-0008-4176-1056
Imma RaurellLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
Aurora BarberáLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.ORCID 0000-0002-6201-2643
Juan Manuel PericàsLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
Diana HideLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
Felix ElortzaProteomics Platform, CIC bioGUNE, BRTA (Basque Research & Technology Alliance), Bizkaia Science and Technology Park, 48160 Derio, Spain.ORCID 0000-0001-8839-5438
Joan GenescàLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.
María MartellLiver Diseases, Vall d'Hebron Institut de Recerca (VHIR), Liver Unit, Hospital Universitari Vall d'Hebron (HUVH), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain.ORCID 0000-0002-0935-0029

Funding

Agency for Administration of University and Research 2019FI_B 00395Instituto de Salud Carlos III FI18/0008Instituto de Salud Carlos III PI18/00947, AC18/00033 PI21/00691
6 · The paper itself

Abstract

Molecular markers of dedifferentiation of dysfunctional liver sinusoidal endothelial cells (LSEC) have not been fully elucidated. We aimed at deciphering the molecular profile of dysfunctional LSEC in different pathological scenarios. Flow cytometry was used to sort CD11b

Indexed as

LiverLiver DiseasesAnimalsEndothelial CellsModels, TheoreticalProteomicsRatsanimal modelschronic liver diseaseendothelial dysfunctionliver sinusoidal endothelial cellsproteomics

Identifiers

PMID37569282
PMCPMC10418749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.