Evidence map›Paper›PMID 37568892›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Clinical Characterization and Outcomes of Culture- and Polymerase Chain Reaction-Negative Cases of Infectious Keratitis.

Sarah Atta, Rohan Bir Singh, Keerthana Samanthapudi, Chandrashan Perera, Mahmoud Omar, Shannon Nayyar, Regis P Kowalski, Vishal Jhanji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Observational
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sarah AttaDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-4175-6504
Rohan Bir SinghDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-2426-3900
Keerthana SamanthapudiDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Chandrashan PereraDepartment of Ophthalmology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8104-2824
Mahmoud OmarDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.ORCID 0000-0002-3806-4849
Shannon NayyarDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Regis P KowalskiDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Vishal JhanjiDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
University of Pittsburgh · USMassachusetts Eye and Ear Infirmary · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the clinical presentation, management, and outcomes of culture and polymerase chain reaction (PCR) negative cases of infectious keratitis.

methodsIn this retrospective case series, we evaluated the laboratory and medical records of culture- and PCR-negative cases (2016-2020) reported to a tertiary care center, which were presumed to be infectious keratitis on the basis of clinical history and presentation.

resultsA total of 121 cases with culture-negative keratitis were included in this study. The mean age of the patients was 48.42 ± 1.89 years, and 53.72% were female. At presentation, the presumed etiology was viral in 38.01%, bacterial in 27.27%, fungal in 8.26%, Acanthamoeba in 6.61%, and unlisted in 28.92% of cases. The most common risk factors were a previous history of ocular surface diseases (96.69%) and contact lens use (37.19%). In total, 61.98% of the patients were already on antimicrobial medication at presentation. The initial management was altered in 79 cases (65.29%) during the treatment course. Average presenting and final (post-treatment) visual acuities (VA) were 0.98 ± 0.04 (LogMAR) and 0.42 ± 0.03 (LogMAR), respectively. A significantly higher frequency of patients with a final VA worse than 20/40 (Snellen) had worse VA at initial presentation (

conclusionsWe observed a distinct difference in clinical features among patients with culture-negative and PCR-negative keratitis managed for presumed viral and bacterial infections. Although there was significant variability in presentation and management duration in this cohort, the visual outcomes were generally favorable.

Indexed as

bacterial keratitisculture-negative keratitisherpetic keratitiskeratitisPCR-negative keratitis

Identifiers

PMID37568892
PMCPMC10417528
OpenAlexW4385421890

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.