Evidence map›Paper›PMID 37568806›Full record

ArticleCancers2023

Race and Ethnicity Impacts Overall Survival of Patients with Appendiceal Cancer Who Undergo Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy.

Devon C Freudenberger, Vignesh Vudatha, Luke G Wolfe, Andrea N Riner, Kelly M Herremans, Brian K Sparkman, Leopoldo J Fernandez, Jose G Trevino

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Devon C FreudenbergerDepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.ORCID 0000-0002-9117-0130
Vignesh VudathaDepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.ORCID 0000-0002-3624-3771
Luke G WolfeDepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Andrea N RinerDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0003-2088-5400
Kelly M HerremansDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-0454-0931
Brian K SparkmanDepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.ORCID 0000-0001-9953-5088
Leopoldo J FernandezDepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Jose G TrevinoDepartment of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.
Virginia Commonwealth University · USUniversity of Florida · US

Funding

Tissue Modeling & Drug Development Shared Resources CoreU54CA233444 · NCI · UNIVERSITY OF FLORIDA · PI Chanita A. Hughes-Halbert, Tianze Jiao · 2018 to 2026
$12.1M
Tissue Modeling CoreU54CA233465 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JOYCE M RICHEY · 2018 to 2026
$11.9M
Tissue Modeling CoreU54CA233396 · NCI · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI Ukamaka D. Smith · 2018 to 2026
$9.8M
United for Health Excellence - Living PDX Program (U4HELPP)U54CA283762 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Jose G. Trevino · 2023 to 2026
$5.0M
Training Program for Applied Research and Development in Genomic MedicineT32HG008958 · NHGRI · UNIVERSITY OF FLORIDA · PI Larisa Humma Cavallari, Stephen E. Kimmel · 2018 to 2026
$3.8M
Use of BCL-xL Proteolysis targeting chimeras to treat pancreatic cancerR01CA242003 · NCI · UNIVERSITY OF FLORIDA · PI TREVINO, JOSE G., ZHENG, GUANGRONG · 2019 to 2023
$2.6M
NCI NIH HHS CA093423-13NCI NIH HHS CA233444NCI NIH HHS CA242003NCI NIH HHS R01 CA242003NCI NIH HHS U54 CA233396NCI NIH HHS U54 CA233444NCI NIH HHS U54 CA233465NCI NIH HHS U54 CA283762NHGRI NIH HHS HG008958
6 · The paper itself

Abstract

Appendiceal cancer treatment may include cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We investigated whether patient race/ethnicity influences outcomes and overall survival for patients with appendiceal cancer who undergo CRS/HIPEC. We queried the National Cancer Database for adult patients with appendiceal cancer treated with CRS/HIPEC from 2006 to 2018. Patients were stratified by race/ethnicity: non-Hispanic White (NHW), non-Hispanic Black (NHB), Hispanic, and Other. Sociodemographics and outcomes were compared using descriptive statistics. Kaplan-Meier survival analysis and Log-rank tests assessed differences in overall survival (OS). Cox Multivariate Regression evaluated factors associated with OS. In total, 2532 patients were identified: 2098 (82.9%) NHW, 186 (7.3%) NHB, 127 (5.0%) Hispanic, and 121 (4.8%) Other patients. The sociodemographics were statistically different across groups. The perioperative and postoperative outcomes were similar. OS was significantly different by race/ethnicity (

Indexed as

appendiceal cancercancer survivorshipcytoreductive surgery (CRS)hyperthermic intraperitoneal chemotherapy (HIPEC)racial disparities

Identifiers

PMID37568806
PMCPMC10417044
OpenAlexW4385611215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.