Evidence map›Paper›PMID 37568777›Full record

ArticleCancers2023

In Vivo Thermal Ablation of Deep Intrahepatic Targets Using a Super-Convergent MRgHIFU Applicator and a Pseudo-Tumor Model.

Orane Lorton, Pauline Coralie Guillemin, Andrea Peloso, Yacine M'Rad, Lindsey Alexandra Crowe, Thibaud Koessler, Pierre-Alexandre Poletti, Sana Boudabbous, Alexis Ricoeur, Rares Salomir

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Orane LortonImage Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0002-6500-1093
Pauline Coralie GuilleminImage Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0003-2792-6543
Andrea PelosoVisceral Surgery Division, University Hospitals of Geneva, 1205 Geneva, Switzerland.
Yacine M'RadImage Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0003-3295-3386
Lindsey Alexandra CroweRadiology Division, University Hospitals of Geneva, 1205 Geneva, Switzerland.ORCID 0000-0002-2044-1220
Thibaud KoesslerOncology Department, University Hospitals of Geneva, 1205 Geneva, Switzerland.
Pierre-Alexandre PolettiRadiology Division, University Hospitals of Geneva, 1205 Geneva, Switzerland.
Sana BoudabbousImage Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0003-0516-4613
Alexis RicoeurImage Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.ORCID 0000-0001-5443-8428
Rares SalomirImage Guided Interventions Laboratory (GR-949), Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
University of Geneva · CHUniversity Hospital of Geneva · CH

Funding

Swiss National Science Foundation CR320030_185308
6 · The paper itself

Abstract

backgroundHIFU ablation of liver malignancies is particularly challenging due to respiratory motion, high tissue perfusion and the presence of the rib cage. Based on our previous development of a super-convergent phased-array transducer, we aimed to further investigate, in vivo, its applicability to deep intrahepatic targets.

methodsIn a series of six pigs, a pseudo-tumor model was used as target, visible both on intra-operatory MRI and post-mortem gross pathology. The transcostal MRgHIFU ablation was prescribed coplanar with the pseudo-tumor, either axial or sagittal, but deliberately shifted 7 to 18 mm to the side. No specific means of protection of the ribs were implemented. Post-treatment MRI follow-up was performed at D7, followed by animal necropsy and gross pathology of the liver.

resultsThe pseudo-tumor was clearly identified on T1w MR imaging and subsequently allowed the MRgHIFU planning. The peak temperature at the focal point ranged from 58-87 °C. Gross pathology confirmed the presence of the pseudo-tumor and the well-delineated MRgHIFU ablation at the expected locations.

conclusionsThe specific design of the transducer enabled a reliable workflow. It demonstrated a good safety profile for in vivo transcostal MRgHIFU ablation of deep-liver targets, graded as challenging for standard surgery.

Indexed as

high-intensity focused ultrasoundhyperthermialiver ablationtargetingthermal ablationtumor-mimicking RF markers

Identifiers

PMID37568777
PMCPMC10417404
OpenAlexW4385556185

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.