ReviewCancers2023
FLASH Radiotherapy and the Use of Radiation Dosimeters.
Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Global clinical landscape and multidisciplinary translational frontiers of FLASH radiotherapy: a systematic review and visualized bibliometric mapping based on WoSCC and PubMed (2014-2025).Frontiers in medicine · 2026Pooled it
- A systematic review of electron FLASH dosimetry and beam control mechanisms utilized with modified non-clinical LINACs.Journal of applied clinical medical physics · 2025Pooled it
- Development of in situ dosimetry for FLASH proton radiotherapy via organic scintillating fibers.The British journal of radiology · 2026Article
- Evaluation of a Faraday cup-style detector as a beam diagnostic system for ultra-high dose rate (FLASH) electron beams.Journal of applied clinical medical physics · 2026Article
- Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.Medical physics · 2026Article
- One-year follow-up after fractionated ultra-high-dose-rate FLASH radiotherapy in patient with extramammary Paget disease of the scrotum.Precision radiation oncology · 2026Article
- Fiber-Tip Surface-Micromachined Optical Ultrasound Transducer (SMOUT) Probe for Acoustic Detection Induced by Ultrahigh Dose Rate (UHDR) Electron Beam.IEEE sensors journal · 2026Article
- DNA damage and cell death induced by exposure to ultra-high dose rate low-dose pulsed X-rays emitted from a kilojoule plasma focus device.Biological research · 2026Article
- FLASH radiotherapy and immunotherapy synergy: mechanisms, strategies, and clinical translation prospects.Frontiers in immunology · 2026Review
- Microenvironmental remodeling in FLASH radiotherapy.Frontiers in cell and developmental biology · 2026Review
- Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.PloS one · 2026Article
- FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap.Frontiers in immunology · 2026Review
- InAlN/GaN Detectors for Real-Time Dosimetry in Ultra-High Dose Rate FLASH Radiotherapy.IEEE sensors letters · 2026Article
- FLASH Radiotherapy in Lung Cancer: Translational Mechanisms, Preclinical Evidence, and Barriers.Cureus · 2026Review
- Electron and proton FLASH beam dosimetry using unified alanine, EBT-XD, and HD-V2 Gafchromic film dosimeters.Medical physics · 2025Article
- Development and characterization of phantoms to investigate the Flash effect withPhysics and imaging in radiation oncology · 2025Article
- Playing Hard with Si: Challenges and Opportunities for New Materials in Radiation Therapy Dosimetry.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects.World journal of radiology · 2025Review
- Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy.Precision radiation oncology · 2025Article
- FLASH radiotherapy: mechanisms, nanotherapeutic strategy and future development.Nanoscale advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Radiotherapy (RT) using ultra-high dose rate (UHDR) radiation, known as FLASH RT, has shown promising results in reducing normal tissue toxicity while maintaining tumor control. However, implementing FLASH RT in clinical settings presents technical challenges, including limited depth penetration and complex treatment planning. Monte Carlo (MC) simulation is a valuable tool for dose calculation in RT and has been investigated for optimizing FLASH RT. Various MC codes, such as EGSnrc, DOSXYZnrc, and Geant4, have been used to simulate dose distributions and optimize treatment plans. Accurate dosimetry is essential for FLASH RT, and radiation detectors play a crucial role in measuring dose delivery. Solid-state detectors, including diamond detectors such as microDiamond, have demonstrated linear responses and good agreement with reference detectors in UHDR and ultra-high dose per pulse (UHDPP) ranges. Ionization chambers are commonly used for dose measurement, and advancements have been made to address their response nonlinearities at UHDPP. Studies have proposed new calculation methods and empirical models for ion recombination in ionization chambers to improve their accuracy in FLASH RT. Additionally, strip-segmented ionization chamber arrays have shown potential for the experimental measurement of dose rate distribution in proton pencil beam scanning. Radiochromic films, such as Gafchromic
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.