ReviewCancers2023
The Vermiform Appendix and Its Pathologies.
Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Suspected Congenital Absence of the Vermiform Appendix in a 13-Year-Old Girl: A Case Report.Cureus · 2026Article
- Incidental serrated lesions of the appendix: analysis of 2,137 appendectomy specimens.Journal of pathology and translational medicine · 2026Article
- Diagnostic Performance of Interleukin-6 (IL-6) and Membrane Glycoprotein Cluster of Differentiation-64 (CD64) for Acute Appendicitis in Girls Presenting with Lower Abdominal Pain.Diagnostics (Basel, Switzerland) · 2026Article
- Complete subserosal embedding of the appendix-cecal complex presenting as a non-visualized appendix during pediatric laparoscopic appendectomy: a case report.Frontiers in surgery · 2026Article
- Case Report: Incarcerated femoral hernia of the appendix with incidental discovery of goblet cell carcinoma.Frontiers in medicine · 2026Article
- Changing trends in appendiceal pathology: a 16-year retrospective extension study of surgically removed appendices in a tropical teaching hospital.BMC gastroenterology · 2025Article
- Emergency surgical conditions in geriatric patients: current research landscape.International journal of emergency medicine · 2025Review
- Article
- Transcecal endoscopic appendectomy and endoscopic submucosal dissection with hand-suturing-assisted traction and closure technique.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025Article
- Acute Appendicitis or Appendiceal Diverticulitis? A Case Report and Systematic Literature Review.Clinics and practice · 2025Review
- Extramedullary Hematopoiesis in the Appendix Associated With Myelodysplastic Syndrome: A Case Report.Cureus · 2025Article
- Case Report: Imaging and pathological analysis of intra-abdominal aggressive fibromatosis with abscess.Frontiers in oncology · 2025Article
- A Case of Transduodenal Endoscopic Ultrasound-Guided Biopsy of an Appendiceal Lesion.ACG case reports journal · 2024Article
- Use of the vertebrae and iliac bone as references for localizing the appendix vermiformis in computed tomography.World journal of radiology · 2024Article
- Clinical significance of appendicoliths in elderly patients over eighty years old undergoing emergency appendectomy: A single-center retrospective study.World journal of gastrointestinal surgery · 2024Article
- An Unusual Presentation of Acute Appendicitis Mimicking Sigmoid Diverticulitis: A Case Report.Cureus · 2024Article
- Meta-analysis of postoperative incision infection risk factors in colorectal cancer surgery.Frontiers in surgery · 2024Article
- Incidental High-Grade Appendiceal Mucinous Neoplasm.CRSLS : MIS case reports from SLSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The vermiform appendix is a muscular cylindrical structure originating near the junction of the cecum and ileum, averaging 9 cm (5-35 cm) in size. As the most mobile viscera, it can adopt several positions, the most common being the retrocecal position. Perceived as an atavistic organ lacking physiological relevance, the vermiform appendix appears to be involved in immune function, serving in the maturation of B lymphocytes and the production of immunoglobulin A, in endocrine function, excreting amines and hormones in the 2-3 mL of mucus secreted daily, and in digestive function, by storing beneficial bacteria from where they can recolonize the colon. With a lumen of about 6 mm, the vermiform appendix has a reduced storage capacity, so any blockage of the appendix with fecoliths (fecaliths), seeds derailed from the colon, or enlarged lymph nodes prevents drainage and intraluminal accumulation of secreted mucus. Unable to relax, the appendix wall severely limits its intraluminal volume, so mucus accumulation leads to inflammation of the appendix, known generically as appendicitis. In addition, the vermiform appendix may be the site of the development of neoplastic processes, which may or may not involve mucus production, some of which can significantly affect the standard of living and ultimately lead to death. In general, mucinous tumors may have a better prognosis than non-mucinous tumors. This review takes a comprehensive path, starting by describing the anatomy and embryology of the vermiform appendix and further detailing its inflammatory pathologies, pathologies related to congenital anomalies, and appendix tumors, thus creating an up-to-date framework for better understanding, diagnosis, and treatment of these health problems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.