ArticleCancers2023
Intraoperative Contrast-Enhanced Ultrasonography (Io-CEUS) in Minimally Invasive Thoracic Surgery for Characterization of Pulmonary Tumours: A Clinical Feasibility Study.
Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Intraoperative Contrast-Enhanced Ultrasound Versus Traditional Intraoperative Ultrasound for Detecting Lung Nodules During Robotic-assisted Thoracic Surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Article
- Bridging the sensory gap: intraoperative lung ultrasound for deep pulmonary nodule localization in totally endoscopic robotic thoracic surgery.Updates in surgery · 2026Article
- Global trends and academic landscapes of ultrasound applications in lung cancer research: a bibliometric analysis (2000-2024).Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Intraoperative Lung Ultrasound in the Detection of Pulmonary Nodules: A Valuable Tool in Thoracic Surgery.Diagnostics (Basel, Switzerland) · 2025Review
- Role of VATS-US in identifying and characterizing pulmonary nodules: a narrative review.Frontiers in surgery · 2025Review
- Ultrasound for Intra-Operative Detection of Peri-Centimetric Pulmonary Nodules in Uniportal Video-Assisted Thoracic Surgery (VATS): A Comparison with Conventional Techniques in Multiportal VATS.Journal of clinical medicine · 2024Article
- Performance of Intraoperative Contrast-Enhanced Ultrasound (Io-CEUS) in the Diagnosis of Primary Lung Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Use of a handheld system for interventional ultrasound with puncture and biopsy in an in vitro liver model.Clinical hemorheology and microcirculation · 2024Article
- A novel preoperative image-guided localization for small pulmonary nodule resection using a claw-suture device.Scientific reports · 2023Article
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12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe intraoperative detection of solitary pulmonary nodules (SPNs) continues to be a major challenge, especially in minimally invasive video-assisted thoracic surgery (VATS). The location, size, and intraoperative frozen section result of SPNs are decisive regarding the extent of lung resection. This feasibility study investigates the technical applicability of intraoperative contrast-enhanced ultrasonography (Io-CEUS) in minimally invasive thoracic surgery.
methodsIn this prospective, monocentric clinical feasibility study, n = 30 patients who underwent Io-CEUS during elective minimally invasive lung resection for SPNs between October 2021 and February 2023. The primary endpoint was the technical feasibility of Io-CEUS during VATS. Secondary endpoints were defined as the detection and characterization of SPNs.
resultsIn all patients (female, n = 13; mean age, 63 ± 8.6 years) Io-CEUS could be performed without problems during VATS. All SPNs were detected by Io-CEUS (100%). SPNs had a mean size of 2.2 cm (0.5-4.5 cm) and a mean distance to the lung surface of 2.0 cm (0-6.4 cm). B-mode, colour-coded Doppler sonography, and contrast-enhanced ultrasound were used to characterize all tumours intraoperatively. Significant differences were found, especially in vascularization as well as in contrast agent behaviour, depending on the tumour entity. After successful lung resection, a pathologic examination confirmed the presence of lung carcinomas (n = 17), lung metastases (n = 10), and benign lung tumours (n = 3).
conclusionsThe technical feasibility of Io-CEUS was confirmed in VATS before resection regarding the detection of suspicious SPNs. In particular, the use of Doppler sonography and contrast agent kinetics revealed intraoperative specific aspects depending on the tumour entity. Further studies on Io-CEUS and the application of an endoscopic probe for VATS will follow.
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