Evidence map›Paper›PMID 37568598›Full record

ArticleCancers2023

Extracellular-Vesicle-Based Cancer Panels Diagnose Glioblastomas with High Sensitivity and Specificity.

Melike Mut, Zelal Adiguzel, Canan Cakir-Aktas, Şahin Hanalioğlu, Gamze Gungor-Topcu, Ezgi Kiyga, Ilkay Isikay, Aydan Sarac, Figen Soylemezoglu, Thomas Strobel and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Melike MutDepartment of Neurosurgery, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.ORCID 0000-0002-9601-9907
Zelal AdiguzelTUBİTAK, GEBI, Gebze, Kocaeli 41470, Turkey.
Canan Cakir-AktasInstitute of Neurological Sciences and Psychiatry, Hacettepe University, Ankara 06230, Turkey.
Şahin HanalioğluDepartment of Neurosurgery, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Gamze Gungor-TopcuTUBİTAK, GEBI, Gebze, Kocaeli 41470, Turkey.
Ezgi KiygaTUBİTAK, GEBI, Gebze, Kocaeli 41470, Turkey.
Ilkay IsikayDepartment of Neurosurgery, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Aydan SaracTUBİTAK, GEBI, Gebze, Kocaeli 41470, Turkey.
Figen SoylemezogluDepartment of Pathology, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Thomas StrobelDivision of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.
Elisabet Ampudia-MesiasDivision of Hematology and Oncology, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Charles CameronDivision of Hematology and Oncology, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Tulay AslanDepartment of Neurosurgery, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Eray TekirdasDepartment of Neurosurgery, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Mutlu HayranDepartment of Preventive Oncology, Hacettepe University Cancer Institute, Ankara 06230, Turkey.
Kader Karli OguzDepartment of Radiology, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkey.
Christine HenzlerMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-4566-2211
Nurten SaydamExoMed Diagnostic, Minneapolis, MN 55404, USA.
Okay SaydamDivision of Hematology and Oncology, Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Hacettepe University · TRGebze Technical University · TRUniversity of Minnesota Medical Center · USHacettepe University Hospital · TRMedical University of Vienna · ATUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma is one of the most devastating neoplasms of the central nervous system. This study focused on the development of serum extracellular vesicle (EV)-based glioblastoma tumor marker panels that can be used in a clinic to diagnose glioblastomas and to monitor tumor burden, progression, and regression in response to treatment. RNA sequencing studies were performed using RNA isolated from serum EVs from both patients (

Indexed as

biomarkersextracellular vesiclesglioblastoma

Identifiers

PMID37568598
PMCPMC10417317
OpenAlexW4385308500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.