Evidence map›Paper›PMID 37568596›Full record

ReviewCancers2023

The Role of Colonoscopy in the Management of Individuals with Lynch Syndrome: A Narrative Review.

Valentina D'Angelo, Daniela Rega, Pietro Marone, Elena Di Girolamo, Corrado Civiletti, Fabiana Tatangelo, Francesca Duraturo, Marina De Rosa, Mario de Bellis, Paolo Delrio

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Valentina D'AngeloDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-4877-9979
Daniela RegaColorectal Surgical Oncology, Department of Abdominal Oncology, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0001-8326-050X
Pietro MaroneDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Elena Di GirolamoDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Corrado CivilettiDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Fabiana TatangeloDivision of AnatomicPathology and Cytopathology, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-9943-6079
Francesca DuraturoDepartment of Molecular Medicine and Biomedical Technology, School of Medicine, University Federico II, 80138 Naples, Italy.ORCID 0000-0002-0787-6182
Marina De RosaDepartment of Molecular Medicine and Biomedical Technology, School of Medicine, University Federico II, 80138 Naples, Italy.ORCID 0000-0002-4752-5678
Mario de BellisDivision of Gastroenterology and Gastrointestinal Endoscopy, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Paolo DelrioColorectal Surgical Oncology, Department of Abdominal Oncology, Istituto Nazionale Tumori-IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-4271-4939
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The history of Lynch syndrome changed definitively in 2000, when a study published in Gastroenterology demonstrated a significant reduction in mortality among individuals with Lynch syndrome who undergo regular endoscopic surveillance. As a consequence of this clinical evidence, all scientific societies developed guidelines, which highlighted the role of colonoscopy in the management of Lynch syndrome, especially for individuals at high risk of colorectal cancer. Over the years, these guidelines were modified and updated. Specialized networks were developed in order to standardize endoscopic surveillance programs and evaluate all the clinical data retrieved by the results of colonoscopies performed for both the screening and the surveillance of individuals with Lynch syndrome. Recent data show that the impact of colonoscopy (with polypectomy) on the prevention of colorectal cancer in individuals with Lynch syndrome is less significant than previously thought. This narrative review summarizes the current discussion, the hypotheses elaborated and the algorithms depicted for the management of individuals with Lynch Syndrome on the basis of the recent data published in the literature.

Indexed as

colonoscopycolorectal cancerincident cancer riskLynch syndromemismatch-repair deficiencysurveillance

Identifiers

PMID37568596
PMCPMC10417258
OpenAlexW4385289034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.