Evidence map›Paper›PMID 37568583›Full record

ArticleCancers2023

Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases.

Polina Rusina, Erik Gandalipov, Yana Abdusheva, Maria Panova, Alexandra Burdenkova, Vasiliy Chaliy, Maria Brachs, Oleg Stroganov, Ksenia Guzeeva, Igor Svitanko and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Polina RusinaZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.
Erik GandalipovLaboratory of Solution Chemistry and Advanced Materials Technologies, ITMO University, 9 Lomonosov Street, 191002 Saint Petersburg, Russia.ORCID 0000-0003-3931-1853
Yana AbdushevaZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.
Maria PanovaZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.
Alexandra BurdenkovaZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.
Vasiliy ChaliyZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.ORCID 0000-0002-5601-9144
Maria BrachsTreamid Therapeutics GmbH, c/o CoLaborator (Bayer), Building S141, Muellerstraβe 178, 13353 Berlin, Germany.
Oleg StroganovBioMolTech Corp., Toronto, ON M2L 1L1, Canada.ORCID 0000-0001-6190-823X
Ksenia GuzeevaHigher School of Economics, National Research University, 20 Myasnitskaya Street, 101000 Moscow, Russia.
Igor SvitankoZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.
Alexander ShtilBlokhin National Medical Research Center of Oncology, 24 Kashirskoye Shosse, 115522 Moscow, Russia.
Fedor NovikovZelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Avenue, 119991 Moscow, Russia.ORCID 0000-0001-5343-7722
National Research University Higher School of Economics · RUN.D. Zelinsky Institute of Organic Chemistry · RUBayer (Germany) · DEITMO University · RUNational Research Nuclear University MEPhI · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rational design of cyclin-dependent protein kinase (CDK) inhibitors presumes the development of approaches for accurate prediction of selectivity and the activity of small molecular weight anticancer drug candidates. Aiming at attenuation of general toxicity of low selectivity compounds, we herein explored the new chemotype of imidazole-4-N-acetamide substituted derivatives of the pan-CDK inhibitor PHA-793887. Newly synthesized compounds

Indexed as

CDK1CDK2CDK5CDK9cyclin dependent kinasesfree energy calculationmolecular dockingmolecular dynamicsNEQselectivity predictiontumor cell lines

Identifiers

PMID37568583
PMCPMC10417023
OpenAlexW4385278170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.