Evidence map›Paper›PMID 37568543›Full record

ReviewJournal of clinical medicine2023

Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging.

Johanna Päivärinta, Ioanna A Anastasiou, Niina Koivuviita, Kanishka Sharma, Pirjo Nuutila, Ele Ferrannini, Anna Solini, Eleni Rebelos

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Johanna PäivärintaDepartment of Medicine, Division of Nephrology, Turku University Hospital, 20521 Turku, Finland.
Ioanna A Anastasiou1st Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece.ORCID 0000-0002-7560-0575
Niina KoivuviitaDepartment of Medicine, Division of Nephrology, Turku University Hospital, 20521 Turku, Finland.
Kanishka SharmaDepartment of Imaging, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK.
Pirjo NuutilaTurku PET Centre, 20521 Turku, Finland.ORCID 0000-0001-9597-338X
Ele FerranniniCNR, Institute of Clinical Physiology, 56124 Pisa, Italy.
Anna SoliniDepartment of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, 56124 Pisa, Italy.ORCID 0000-0002-7855-8253
Eleni RebelosTurku PET Centre, 20521 Turku, Finland.
Turku University Hospital · FIUniversity of Pisa · ITIstituto di Fisiologia Clinica · ITNational and Kapodistrian University of Athens · GRUniversity of Sheffield · GB

Funding

Finnish Medical Foundation 5421
6 · The paper itself

Abstract

Thanks to technical advances in the field of medical imaging, it is now possible to study key features of renal anatomy and physiology, but so far poorly explored due to the inherent difficulties in studying both the metabolism and vasculature of the human kidney. In this narrative review, we provide an overview of recent research findings on renal perfusion, oxygenation, and substrate uptake. Most studies evaluating renal perfusion with positron emission tomography (PET) have been performed in healthy controls, and specific target populations like obese individuals or patients with renovascular disease and chronic kidney disease (CKD) have rarely been assessed. Functional magnetic resonance (fMRI) has also been used to study renal perfusion in CKD patients, and recent studies have addressed the kidney hemodynamic effects of therapeutic agents such as glucagon-like receptor agonists (GLP-1RA) and sodium-glucose co-transporter 2 inhibitors (SGLT2-i) in an attempt to characterise the mechanisms leading to their nephroprotective effects. The few available studies on renal substrate uptake are discussed. In the near future, these imaging modalities will hopefully become widely available with researchers more acquainted with them, gaining insights into the complex renal pathophysiology in acute and chronic diseases.

Indexed as

functional magnetic resonance imagingpositron emission tomographyrenal oxygenationrenal perfusionrenal substrate uptake

Identifiers

PMID37568543
PMCPMC10420088
OpenAlexW4385611554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.