ArticleJournal of clinical medicine2023
Cold Plasma Therapy in Chronic Wounds-A Multicenter, Randomized Controlled Clinical Trial (Plasma on Chronic Wounds for Epidermal Regeneration Study): Preliminary Results.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06543316 (Accelerated Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- A dual-index framework for cold atmospheric plasma dosing: A meta-analysis of parametric control from volumetric redox flux to redox homeostatic status.Redox biology · 2026Pooled it
- [A systematic review and Bayesian network meta-analysis of the effectiveness of non-pharmacological interventions in treating chronic wound pain in patients].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Pooled it
- Antibiotic class-dependent degradation mechanisms and resistance gene elimination by dielectric barrier discharge cold plasma technology for wastewater treatment.RSC advances · 2026Review
- Active Free Radical Cold Atmosphere Plasma Promotes Healing of Diabetes Foot Ulcer: Mechanism and Challenge.Diabetes/metabolism research and reviews · 2026Review
- Cold Atmospheric Plasma in Wound Healing: Molecular Mechanism of Action.International journal of molecular sciences · 2026Review
- Cold Atmospheric Plasma-Aerosol Treatment of Equine Antibiotic-Resistant Wound Infection: A Preliminary Case Series.Animals : an open access journal from MDPI · 2026Article
- Cold Atmospheric Plasma as a Potential Disease-Modifying Therapy for Osteoarthritis.Biomedicines · 2026Review
- Gas Therapies for Chronic Wounds: Comparative Effectiveness, Safety, and Evidence Certainty-A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2026Article
- Challenges in the standardization of in vitro cytotoxicity assays for comparative risk assessment of cold atmospheric pressure plasma devices.Scientific reports · 2026Article
- Jet Cold Plasma at Atmospheric Air Pressure for Venous Ulcers: A Randomized Clinical Trial.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- Medical gas plasma modifies Nrf2 signaling in diabetic wound healing.Journal of advanced research · 2026Article
- Plasma-activated water: a dual-action disinfectant and wound-healing therapy for diabetes-related foot infections.FEMS microbiology reviews · 2026Review
- Electrochemical Detection of NO and CaPlasma chemistry and plasma processing · 2026Article
- Cold atmospheric plasma mediates antibiofilm activity and sensitization to further plasma and antibiotic challenges againstFEMS microbes · 2026Article
- Cold atmospheric plasma is a promising strategy for treating diabetic retinopathy.Journal of translational medicine · 2025Review
- Free Radicals in Health and Disease.MedComm · 2025Review
- Trypan Blue Image-Guided Removal of Surface-Based Bacterial Biofilms from Chicken Tissue Using Cold Atmospheric Pressure Plasma.Plasma (Basel, Switzerland) · 2025Article
- Cold Plasma Generates a Localized Inflammatory Response and Promotes Muscle Repair.Advanced therapeutics · 2025Article
- YAP/TAZ, beta-catenin, and TGFb pathway activation in medical plasma-induced wound healing in diabetic mice.Journal of advanced research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic wounds (CWs) pose a significant health challenge in clinical practice. Standard wound therapy (SWT) is currently considered the gold standard. However, recent evidence suggests that cold plasma therapy (CPT) holds promise for improving CWs. In light of this, the POWER study was conducted as a multicenter, randomized clinical trial to investigate the effect of large-area plasma application compared with SWT in patients with chronic, non-healing arterial or venous wounds on the lower leg. To analyze the interim results, we employed a comprehensive range of statistical tests, including both parametric and non-parametric methods, as well as GLS model regression and an ordinal mixed model. Our findings clearly demonstrate that CPT therapy significantly accelerates wound closure compared with SWT. In fact, complete wound closure was exclusively observed in the CPT group during the intervention period. Additionally, the CPT group required significantly less antibiotic therapy (4%) compared with the SWT group (23%). Furthermore, CPT led to a significant reduction in wound pain and improved quality of life compared with SWT. In conclusion, the study highlights that the combination of CPT and SWT surpasses monotherapy with SWT alone.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.