Evidence map›Paper›PMID 37568452›Full record

ReviewJournal of clinical medicine2023

Advancing Precision Medicine in Myocarditis: Current Status and Future Perspectives in Endomyocardial Biopsy-Based Diagnostics and Therapeutic Approaches.

Christian Baumeier, Dominik Harms, Ganna Aleshcheva, Ulrich Gross, Felicitas Escher, Heinz-Peter Schultheiss

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Christian BaumeierInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Dominik HarmsInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.ORCID 0000-0003-0729-7321
Ganna AleshchevaInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Ulrich GrossInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
Felicitas EscherDepartment of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Campus Virchow Klinikum, 13353 Berlin, Germany.ORCID 0000-0003-0678-5681
Heinz-Peter SchultheissInstitute of Cardiac Diagnostics and Therapy, IKDT GmbH, 12203 Berlin, Germany.
CS Diagnostics · DEDeutsches Herzzentrum der Charité · DERobert Koch Institute · DE

Funding

Federal Ministry of Economic Affairs and Climate Action Germany KK5175802AP2, KK5463501AP2, KK5463901AP2Investitionsbank Berlin 10169096, 10169098, 10169028
6 · The paper itself

Abstract

The diagnosis and specific and causal treatment of myocarditis and inflammatory cardiomyopathy remain a major clinical challenge. Despite the rapid development of new imaging techniques, endomyocardial biopsies remain the gold standard for accurate diagnosis of inflammatory myocardial disease. With the introduction and continued development of immunohistochemical inflammation diagnostics in combination with viral nucleic acid testing, myocarditis diagnostics have improved significantly since their introduction. Together with new technologies such as miRNA and gene expression profiling, quantification of specific immune cell markers, and determination of viral activity, diagnostic accuracy and patient prognosis will continue to improve in the future. In this review, we summarize the current knowledge on the pathogenesis and diagnosis of myocarditis and inflammatory cardiomyopathies and highlight future perspectives for more in-depth and specialized biopsy diagnostics and precision, personalized medicine approaches.

Indexed as

antiviral therapyendomyocardial biopsygene expression profileinflammatory cardiomyopathymiRNAmyocarditisnext-generation sequencingprecision medicineviral myocarditis

Identifiers

PMID37568452
PMCPMC10419903
OpenAlexW4385462285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.