Evidence map›Paper›PMID 37568339›Full record

ArticleJournal of clinical medicine2023

De Novo Lipogenesis-Related Monounsaturated Fatty Acids in the Blood Are Associated with Cardiovascular Risk Factors in HFpEF Patients.

Matthias Bock, Clemens von Schacky, Johannes Scherr, Elke Lorenz, Benjamin Lechner, Alexander Krannich, Rolf Wachter, André Duvinage, Frank Edelmann, Katharina Lechner

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Matthias BockDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Clemens von SchackyOmegametrix, 82152 Martinsried, Germany.
Johannes ScherrUniversity Center for Prevention and Sports Medicine, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.ORCID 0000-0001-9948-1024
Elke LorenzDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.
Benjamin LechnerDepartment of Internal Medicine IV, Ludwig-Maximilians University, 80336 Munich, Germany.
Alexander KrannichCharité, Universitätsmedizin Berlin, 13353 Berlin, Germany.
Rolf WachterClinic and Policlinic for Cardiology, University Hospital Leipzig, 04103 Leipzig, Germany.
André DuvinageDZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance, Munich, Germany.
Frank EdelmannDeutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Katharina LechnerDepartment of Cardiology, German Heart Centre Munich, Technical University of Munich, Lazarettstraße 36, 80636 Munich, Germany.ORCID 0000-0002-3582-3512
German Centre for Cardiovascular Research · DECharité - Universitätsmedizin Berlin · DEDeutsches Herzzentrum München · DEHumboldt-Universität zu Berlin · DELudwig-Maximilians-Universität München · DEUniversitätsmedizin Göttingen · DEUniversity of Zurich · CH

Funding

Deutsche Herzstiftung F/19/18
6 · The paper itself

Abstract

De novo lipogenesis (DNL)-related monounsaturated fatty acids (MUFAs) in the blood are associated with incident heart failure (HF). This observation's biological plausibility may be due to the potential of these MUFAs to induce proinflammatory pathways, endoplasmic reticulum stress, and insulin resistance, which are pathophysiologically relevant in HF. The associations of circulating MUFAs with cardiometabolic phenotypes in patients with heart failure with a preserved ejection fraction (HFpEF) are unknown. In this secondary analysis of the Aldosterone in Diastolic Heart Failure trial, circulating MUFAs were analysed in 404 patients using the HS-Omega-3-Index

Indexed as

aerobic capacityde novo lipogenesis-related fatty acidsheart failureHFpEFmetabolic phenotypemonounsaturated fatty acids

Identifiers

PMID37568339
PMCPMC10419368
OpenAlexW4385345220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.